Academic Journal
The Dissolution of Double Holliday Junctions
| العنوان: | The Dissolution of Double Holliday Junctions |
|---|---|
| المؤلفون: | Published Online September, Cold Spring Harb Perspect Biol, Ylli Doksani, Titia De Lange, Dysfunctional Telomeres, At Functional, James M. Daley, William A. Gaines, Anuja Mehta, James E. Haber, Holliday Junction Resolvases, Haley D. M. Wyatt, Stephen C. West, Andrés Aguilera, Hélène Gaillard, Lorraine S. Symington, Christian Bernd Schiller, Florian Ulrich Seifert, Anna H. Bizard, Ian D. Hickson |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://delangelab.rockefeller.edu/assets/file/Doksani+CSHL+2014.pdf. |
| المجموعة: | CiteSeerX |
| الوصف: | Telomeres have evolved to protect the ends of linear chromosomes from themyriad of threats posed by the cellular DNA damage signaling and repair pathways. Mammalian telomeres have to block nonhomologous end joining (NHEJ), thus preventing chromosome fusions; they need to control homologous recombination (HR), which could change telomere lengths; they have to avoid activating the ATM (ataxia telangiectasia mutated) and ATR (ATM- and RAD3-related) kinase pathways, which could induce cell cycle arrest; and they have to protect chromosome ends from hyperresection. Recent studies of telomeres have provided insights into themechanismsofNHEJandHR,how thesedouble-strandbreak (DSB) repair pathways can be thwarted, and how telomeres have co-opted DNA repair factors to help in the protection of chromosome ends. These aspects of telomere biology are |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.659.377; http://delangelab.rockefeller.edu/assets/file/Doksani+CSHL+2014.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.659.377 http://delangelab.rockefeller.edu/assets/file/Doksani+CSHL+2014.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.ACF7A17A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |