Academic Journal
THC exposure during adolescence does not modify nicotine reinforcing effects and relapse in adult male mice.
| العنوان: | THC exposure during adolescence does not modify nicotine reinforcing effects and relapse in adult male mice. |
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| المؤلفون: | Flores, África, Maldonado, Rafael, Berrendero, Fernando |
| بيانات النشر: | Psychopharmacology |
| سنة النشر: | 2019 |
| المجموعة: | Universidad Francisco de Vitoria: Depósito Digital FV (DDFV) |
| مصطلحات موضوعية: | Adolescence, Mice, Nicotine, Relapse, Reward, Δ9-tetrahydrocannabinol |
| الوصف: | Rationale: Cannabis use is typically initiated during adolescence, and different studies suggest that adolescent cannabinoid exposure may increase the risk for drug addiction in adulthood. Objectives: This study investigated the effects of adolescent exposure to the main psychoactive component of cannabis, Δ9-tetrahydrocannabinol (THC), in the reinforcing properties of nicotine in adult male mice. Possible alterations in relapse to nicotine-seeking behaviour in adult animals due to THC adolescent exposure were also evaluated. Methods: Adolescent mice were exposed to escalating doses of THC from PND35 to PND49. When mice reached adulthood (PND70), surgical procedures were applied for further behavioural evaluation. Nicotine self-administration sessions were conducted consecutively for 10 days. Following extinction, mice were tested for cue- and stress-induced reinstatement of nicotine-seeking behaviour. Results: Adolescent THC treatment did not modify acquisition and extinction of nicotine self-administration in adulthood. Moreover, THC exposure did not alter relapse to nicotine seeking induced by stress or nicotine-associated cues. Conclusions: These results suggest that a history of exposure to THC during adolescence under these particular conditions does not modify the reinforcing effects and seeking behaviour of nicotine in the adult period. ; pre-print ; 256 KB |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0033-3158 |
| Relation: | https://link.springer.com/article/10.1007%2Fs00213-019-05416-8; http://hdl.handle.net/10641/1846 |
| DOI: | 10.1007/s00213-019-05416-8 |
| الاتاحة: | http://hdl.handle.net/10641/1846 https://doi.org/10.1007/s00213-019-05416-8 |
| Rights: | Atribución-NoComercial-SinDerivadas 3.0 España ; http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ; openAccess |
| رقم الانضمام: | edsbas.ACF6A298 |
| قاعدة البيانات: | BASE |
| تدمد: | 00333158 |
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| DOI: | 10.1007/s00213-019-05416-8 |