التفاصيل البيبلوغرافية
| العنوان: |
Chan–Lam Amination of Secondary and Tertiary Benzylic Boronic Esters |
| المؤلفون: |
James D. Grayson (6588947), Francesca M. Dennis (11026013), Craig C. Robertson (1297533), Benjamin M. Partridge (2007220) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Microbiology, Molecular Biology, Evolutionary Biology, Marine Biology, Astronomical and Space Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, single-electron, two-electron process, reaction mechanism, boronic esters, allylic boronic esters, alkylboron reagent, transition-metal-mediated transform., alkyl amine products, Tertiary Benzylic Boronic Esters, Amination, Secondary, transmetalation, Initial investigation, mono-alkylation, benzylic, Chan, Cu, aniline |
| الوصف: |
We report a Chan–Lam coupling reaction of benzylic and allylic boronic esters with primary and secondary anilines to form valuable alkyl amine products. Both secondary and tertiary boronic esters can be used as coupling partners, with mono-alkylation of the aniline occurring selectively. This is a rare example of a transition-metal-mediated transformation of a tertiary alkylboron reagent. Initial investigation into the reaction mechanism suggests that transmetalation from B to Cu occurs through a single-electron, rather than a two-electron process. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Chan_Lam_Amination_of_Secondary_and_Tertiary_Benzylic_Boronic_Esters/14846888 |
| DOI: |
10.1021/acs.joc.1c00976.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.joc.1c00976.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.ACF68EA6 |
| قاعدة البيانات: |
BASE |