Academic Journal
Functional brain imaging using a blood oxygenation sensitive steady state
| العنوان: | Functional brain imaging using a blood oxygenation sensitive steady state |
|---|---|
| المؤلفون: | Miller, Karla L., Hargreaves, Brian A., Lee, Jongho, Ress, David, Christopher deCharms, R., Pauly, John M. |
| المصدر: | Magnetic Resonance in Medicine ; volume 50, issue 4, page 675-683 ; ISSN 0740-3194 1522-2594 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2003 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Blood oxygenation level dependent (BOLD) functional MRI (fMRI) is an important method for functional neuroimaging that is sensitive to changes in blood oxygenation related to brain activation. While BOLD imaging has good spatial coverage and resolution relative to other neuroimaging methods (such as positron emission tomography (PET)), it has significant limitations relative to other MRI techniques, including poor spatial resolution, low signal levels, limited contrast, and image artifacts. These limitations derive from the coupling of BOLD functional contrast to sources of image degradation. This work presents an alternative method for fMRI that may over‐come these limitations by establishing a blood oxygenation sensitive steady‐state (BOSS) that inverts the signal from deoxygenated blood relative to the water signal. BOSS fMRI allows the imaging parameters to be optimized independently of the functional contrast, resulting in fewer image artifacts and higher signal‐to‐noise ratio (SNR). In addition, BOSS fMRI has greater functional contrast than BOLD. BOSS fMRI requires careful shimming and multiple acquisitions to obtain a precise alignment of the magnetization to the SSFP frequency response. Magn Reson Med 50:675–683, 2003. © 2003 Wiley‐Liss, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/mrm.10602 |
| الاتاحة: | http://dx.doi.org/10.1002/mrm.10602 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmrm.10602 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mrm.10602 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.ACC4833E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/mrm.10602 |
|---|