Academic Journal
In Vitro and In Vivo Neuroprotective Effects of Sarcosine
| العنوان: | In Vitro and In Vivo Neuroprotective Effects of Sarcosine |
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| المؤلفون: | Tanas, Arzugül, Tozlu, Özlem Özdemir, Gezmiş, Tuğba, Hacimüftüoğlu, Ahmet, Abd El-Aty, A. M., Ceylan, Onur, Mardinoğlu, Adil, Türkez, Hasan |
| المساهمون: | Ngamli Fewou, Simon |
| المصدر: | BioMed Research International ; volume 2022, issue 1 ; ISSN 2314-6133 2314-6141 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by behavioral and psychological symptoms in addition to cognitive impairment and loss of memory. The exact pathogenesis and genetic background of AD are unclear and there remains no effective treatment option. Sarcosine, an n‐methyl derivative of glycine, showed a promising therapeutic strategy for some cognitive disorders. To our knowledge, the impacts of sarcosine supplementation against AD have not yet been elucidated. Therefore, we aimed to determine the neuroprotective potential of sarcosine in in vitro and in vivo AD model. In vitro studies have demonstrated that sarcosine increased the percentage of viable cells against aluminum induced neurotoxicity. In AlCl 3 ‐induced rat model of AD, the level of antioxidant capacity was significantly decreased and expression levels of APP , BACE1 , TNF-α , APH1A, and PSENEN genes were elevated compared to the control group. Additionally, histopathological examinations of the hippocampus of AlCl 3 ‐induced rat brains showed the presence of neurofibrillary tangles (NFTs). However, the administration of sarcosine produced marked improvement and protection of AD‐associated pathologies induced by AlCl 3 in experimental rats. Therefore, this investigation may contribute to design novel therapeutic strategies using sarcosine for the management of AD pathologies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1155/2022/5467498 |
| الاتاحة: | https://doi.org/10.1155/2022/5467498 http://downloads.hindawi.com/journals/bmri/2022/5467498.pdf http://downloads.hindawi.com/journals/bmri/2022/5467498.xml https://onlinelibrary.wiley.com/doi/pdf/10.1155/2022/5467498 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.ACAA8063 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2022/5467498 |
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