Academic Journal
THE IMPACT OF CARDIAC RESYNCHRONISATION THERAPY ON TGF-{beta} 1 SIGNAL PATHWAY IN ISCHAEMIC CARDIOMYOPATHY
| العنوان: | THE IMPACT OF CARDIAC RESYNCHRONISATION THERAPY ON TGF-{beta} 1 SIGNAL PATHWAY IN ISCHAEMIC CARDIOMYOPATHY |
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| المؤلفون: | Chen, Yongle, Cheng, Leilei, Yao, Haohua, Chen, Haiyan, Pan, Cuizhen, Shu, Xianhong |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2012 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Basic research of cardiovascular disease |
| الوصف: | Objectives To investigate the latent impact of cardiac resynchronisation therapy on TGF-β 1 signal pathway in Beagles with ischaemic cardiomyopathy. Methods Twenty adult Beagles were divided into group A (CRT group) and group B (non-CRT group). All of them were chest opened and had heart failure after a ligature in the first diagonal branch. A left ventricular epicardial lead, a right atrium and a right ventricle leads together with the pacemaker were implanted. The pacing was started in group A after myocardial infarction, but was not started in group B. After 4 weeks of CRT, group A was divided into group C (CRT response group) and group D (CRT non-response group). Myocardial tissues were collected from the marginal area of myocardial infarction. The expressions of TGF-β 1, p-Smad2/3, and Smad2/3 in group B, group C, and group D were investigated, respectively. Results The TGF-β 1, p-Smad2/3, and Smad2/3 were expressed at low levels in normal myocardial tissues. There showed a significant elevation of the expression of TGF-β 1, p-Smad2/3, and Smad2/3 at the marginal area of myocardial infarction after the first diagonal branch was ligatured. The expression of TGF-β 1, p-Smad2/3, and Smad2/3 in Group C and Group D were both higher than that in normal myocardial tissues. The collagen fibres of the marginal area of myocardial infarction in group C were significant less than that in group B or group D, meanwhile the expression of TGF-β 1, p-Smad2/3, and Smad2/3 in group C were also lower than that in group B and group D p<0.05). Conclusions In the responders of Beagles with ischaemic cardiomyopathy, CRT can inhibit the expression of TGF-β 1, p-Smad2/3, and Smad2/3 and reduce the deposition of collagen fibres, which leads to the improvement of cardiac function. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://heart.bmj.com/cgi/content/short/98/Suppl_2/E88-b; http://dx.doi.org/10.1136/heartjnl-2012-302920a.231 |
| DOI: | 10.1136/heartjnl-2012-302920a.231 |
| الاتاحة: | http://heart.bmj.com/cgi/content/short/98/Suppl_2/E88-b https://doi.org/10.1136/heartjnl-2012-302920a.231 |
| Rights: | Copyright (C) 2012, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.ACA80109 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/heartjnl-2012-302920a.231 |
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