Academic Journal
LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells.
| العنوان: | LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells. |
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| المؤلفون: | Cebrià-Costa, J.P., Pascual-Reguant, L., Gonzalez-Perez, A., Serra-Bardenys, G., Querol, J., Cosín, M., Verde, G., Cigliano, R.A., Sanseverino, W., Segura-Bayona, S., Iturbide Martinez De Albeniz, A., Andreu, D., Nuciforo, P., Bernado-Morales, C., Rodilla, V., Arribas, J., Yelamos, J., de Herreros, A.G., Stracker, T.H., Peiró, S. |
| المصدر: | Oncogene 39, 79-121 (2020) |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2020 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| الوصف: | Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) cell lines and patient-derived xenografts (PDXs) than those from other breast cancer subtypes. ChIP-seq revealed that H3K4ox is located primarily in heterochromatin, where it is involved in chromatin compaction. Knocking down LOXL2 reduces H3K4ox levels and causes chromatin decompaction, resulting in a sustained activation of the DNA damage response (DDR) and increased susceptibility to anticancer agents. This critical role that LOXL2 and oxidized H3 play in chromatin compaction and DDR suggests that functionally targeting LOXL2 could be a way to sensitize TNBC cells to conventional therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | German |
| تدمد: | 0950-9232 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31462706; info:eu-repo/semantics/altIdentifier/wos/WOS:000509849200007; info:eu-repo/semantics/altIdentifier/isbn/0950-9232; info:eu-repo/semantics/; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=57955; urn:isbn:0950-9232; urn:issn:0950-9232 |
| DOI: | 10.1038/s41388-019-0969-1 |
| الاتاحة: | https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=57955 https://doi.org/10.1038/s41388-019-0969-1 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AC56BABF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09509232 |
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| DOI: | 10.1038/s41388-019-0969-1 |