التفاصيل البيبلوغرافية
| العنوان: |
The activities of three enzymes of haem synthesis during hepatic erythropoiesis in the mouse embryo |
| المؤلفون: |
Freshney, R. I., Paul, J. |
| بيانات النشر: |
Company of Biologists |
| سنة النشر: |
1971 |
| المجموعة: |
HighWire Press (Stanford University) |
| مصطلحات موضوعية: |
Articles |
| الوصف: |
Aminolaevulinate synthetase, aminolaevulinate dehydratase, and haem synthetase, three enzymes which may have a regulatory role in haem synthesis, have been determined in liver extracts from different foetal stages of the mouse. Haemoglobin synthesis increases rapidly from early on the 14th day, after fertilization, to reach a maximum late on the 15th day. Aminolaevulinate synthetase reaches a maximum on the 14th day, 24–36 h before the peak of haemoglobin synthesis, aminolaevulinate dehydratase on the 15th day, about 12 h before the peak of haemoglobin synthesis, and haem synthetase on the 17th day. Maximal activity of aminolaevulinate synthetase and aminolaevulinate dehydratase is of only a few hours' duration. Throughout embryonic development the activities of all three enzymes are higher than in the adult liver. The absence of a correlation of enzyme activity with foetal liver cell population changes implies that fluctuations in enzyme activity cannot be explained solely by changes in the proportions of different cell types. The high levels of activity relative to those of adult liver may be related to the high proportion of erythroid cells in the foetal liver. It is concluded that these enzymes are unlikely to form rate-limiting steps during the increase in haemoglobin synthesis between 14 and 15 days. |
| نوع الوثيقة: |
text |
| وصف الملف: |
text/html |
| اللغة: |
English |
| Relation: |
http://dev.biologists.org/cgi/content/short/26/2/313 |
| الاتاحة: |
http://dev.biologists.org/cgi/content/short/26/2/313 |
| Rights: |
Copyright (C) 1971, Company of Biologists |
| رقم الانضمام: |
edsbas.AC36A284 |
| قاعدة البيانات: |
BASE |