التفاصيل البيبلوغرافية
| العنوان: |
One-Pot Synthesis of Unprotected 2‑Acylpyrroles from 1,2,3 - Triazoles and 2‑Hydroxymethylallyl Carbonates |
| المؤلفون: |
Jong-Un Park (8072564), Liang-Zhu Huang (2855771), Ho-Jun Cho (14216167), Boyoung Y. Park (2065717), Ju Hyun Kim (14430) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Microbiology, Genetics, Biotechnology, Evolutionary Biology, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promoted e1cb elimination, ii )- catalyzed, highly regioselective way, double bond isomerization, – h insertion, synthesize multisubstituted 2, >- tosyl triazoles, h pyrroles, readily prepared, pot synthesis, pot approach, n <, multiple bonds, intramolecular cyclization, hydroxymethylallyl carbonates, high efficiency, approach represents |
| الوصف: |
An efficient, tandem one-pot approach to synthesize multisubstituted 2-acylpyrroles from readily prepared N -tosyl triazoles and 2-hydroxymethylallyl carbonates is reported. The reaction proceeds via Rh(II)-catalyzed O–H insertion, [3,3]-sigmatropic rearrangement, Pd(0)-catalyzed oxidative addition, intramolecular cyclization, DBU-promoted E1cB elimination, double bond isomerization, and aromatization, enabling the disconnection and formation of multiple bonds in one reactor. The approach represents a highly regioselective way to access di-, tri-, and tetra-substituted N H pyrroles with high efficiency. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/One-Pot_Synthesis_of_Unprotected_2_Acylpyrroles_from_1_2_3_i_-_i_Triazoles_and_2_Hydroxymethylallyl_Carbonates/21760592 |
| DOI: |
10.1021/acs.joc.2c02602.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.joc.2c02602.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.AC31F427 |
| قاعدة البيانات: |
BASE |