Academic Journal
Evaluating signs of hippocampal neurotoxicity induced by a revisited paradigm of voluntary ethanol consumption in adult male and female Sprague-Dawley rats
| العنوان: | Evaluating signs of hippocampal neurotoxicity induced by a revisited paradigm of voluntary ethanol consumption in adult male and female Sprague-Dawley rats |
|---|---|
| المؤلفون: | Colom-Rocha, Carles, Bis-Humbert, Cristian, García-Fuster, M. Julia |
| المساهمون: | Plan Nacional sobre Drogas, Fundación Instituto d'Investigació Sanitaria de les Illes Balears, Conselleria de Fons Europeus, Universitat i Cultura del Govern de les Illes Balears, RIAPAd, ISCIII, Universitat de Les Illes Balears |
| المصدر: | Pharmacological Reports ; volume 75, issue 2, page 320-330 ; ISSN 1734-1140 2299-5684 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Background Binge alcohol drinking is considered a prominent risk factor for the development of alcohol-use disorders, and could be model in rodents through the standard two-bottle preference choice test. The goal was to recreate an intermittent use of alcohol during 3 consecutive days each week to ascertain its potential impact on hippocampal neurotoxicity (neurogenesis and other neuroplasticity markers), and including sex as a biological variable, given the well-known sex differences in alcohol consumption. Methods Ethanol access was granted to adult Sprague–Dawley rats for 3 consecutive days per week, followed by 4 days of withdrawal, during 6 weeks, mimicking the most common pattern of intake in people, drinking over the weekends in an intensive manner. Hippocampal samples were collected to evaluate signs of neurotoxicity. Results Female rats consumed significantly more ethanol than males, although intake did not escalate over time. Ethanol preference levels remained below 40% over time and did not differ between sexes. Moderate signs of ethanol neurotoxicity were observed in hippocampus at the level of decreased neuronal progenitors (NeuroD + cells), and these effects were independent of sex. No other signs of neurotoxicity were induced by ethanol voluntary consumption when measured through several key cell fate markers (i.e., FADD, Cyt c, Cdk5, NF-L) by western blot analysis. Conclusions Overall, the present results suggest that even though we modeled a situation where no escalation in ethanol intake occurred across time, mild signs of neurotoxicity emerged, suggesting that even the use of ethanol during adulthood in a recreational way could lead to certain brain harm. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s43440-023-00464-6 |
| DOI: | 10.1007/s43440-023-00464-6.pdf |
| DOI: | 10.1007/s43440-023-00464-6/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1007/s43440-023-00464-6 https://link.springer.com/content/pdf/10.1007/s43440-023-00464-6.pdf https://link.springer.com/article/10.1007/s43440-023-00464-6/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.AC318370 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s43440-023-00464-6 |
|---|