Academic Journal
Undescribed Cyclohexene and Benzofuran Alkenyl Derivatives from Choerospondias axillaris , a Potential Hypoglycemic Fruit
| العنوان: | Undescribed Cyclohexene and Benzofuran Alkenyl Derivatives from Choerospondias axillaris , a Potential Hypoglycemic Fruit |
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| المؤلفون: | Ermias Tamiru Weldetsadik, Na Li, Jingjuan Li, Jiahuan Shang, Hongtao Zhu, Yingjun Zhang |
| المصدر: | Foods, Vol 13, Iss 10, p 1495 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Choerospondias axillaris, fruits, alkenyl and benzofuran derivatives, α -glucosidase inhibitory activity, molecular docking, Chemical technology, TP1-1185 |
| الوصف: | The fruit of Choerospondias axillaris (Anacardiaceae), known as south wild jujube in China, has been consumed widely in several regions of the world to produce fruit pastille and leathers, juice, jam, and candy. A comprehensive chemical study on the fresh fruits led to the isolation and identification of 18 compounds, including 7 new ( 1 – 7 ) and 11 known ( 8 – 18 ) comprised of 5 alkenyl (cyclohexenols and cyclohexenones) derivatives ( 1 – 5 ), 3 benzofuran derivatives ( 6 – 8 ), 6 flavonoids ( 9 – 14 ) and 4 lignans ( 15 – 18 ). Their structures were elucidated by extensive spectroscopic analysis. The known lignans 15 – 18 were isolated from the genus Choerospondias for the first time. Most of the isolates exhibited significant inhibitory activity on α -glucosidase with IC 50 values from 2.26 ± 0.06 to 43.9 ± 0.96 μM. Molecular docking experiments strongly supported the potent α -glucosidase inhibitory activity. The results indicated that C. axillaris fruits could be an excellent source of functional foods that acquire potential hypoglycemic bioactive components. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2304-8158 |
| Relation: | https://www.mdpi.com/2304-8158/13/10/1495; https://doaj.org/toc/2304-8158; https://doaj.org/article/ec4b9ec8945746f191b5c8bd085d776e |
| DOI: | 10.3390/foods13101495 |
| الاتاحة: | https://doi.org/10.3390/foods13101495 https://doaj.org/article/ec4b9ec8945746f191b5c8bd085d776e |
| رقم الانضمام: | edsbas.AC2CB0D6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23048158 |
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| DOI: | 10.3390/foods13101495 |