Academic Journal
CRTH2 Is Not Involved in the Anti-Enteropooling Effect of PGD 2 in the Small Intestine
| العنوان: | CRTH2 Is Not Involved in the Anti-Enteropooling Effect of PGD 2 in the Small Intestine |
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| المؤلفون: | Prenn, C., Heinemann, A., Schuligoi, R., Peskar, B.A. |
| المصدر: | Pharmacology ; volume 81, issue 3, page 236-240 ; ISSN 0031-7012 1423-0313 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2008 |
| الوصف: | The majority of prostaglandins (PGs) are known to induce intestinal fluid secretion (enteropooling). In contrast, PGD 2 has been demonstrated to inhibit fluid secretion induced by other PGs. This study was aimed to investigate, by the use of selective agonists/antagonists, which type of PGD 2 receptor mediates this inhibitory effect. The DP1 agonist BW245C dose-dependently inhibited the enteropooling effect of 16,16-dimethyl-PGE 2 . This inhibition was counteracted by the DP1 antagonist BWA868C. In contrast, the CRTH2 receptor does not seem to be involved in the anti-enteropooling effect of PGD 2 , since the selective agonists 13,14-dihydro-15-keto-PGD 2 and 15(R)-15-methyl-PGD 2 were without effect. Therefore, our results suggest that the inhibitory effect of PGD 2 in the small intestine is mediated via activation of the DP1 receptor. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000113730 |
| الاتاحة: | http://dx.doi.org/10.1159/000113730 https://www.karger.com/Article/Pdf/113730 |
| Rights: | https://www.karger.com/Services/SiteLicenses ; https://www.karger.com/Services/SiteLicenses |
| رقم الانضمام: | edsbas.ABE469D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000113730 |
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