Academic Journal
An Aqueous Electrolyte Gated Artificial Synapse with Synaptic Plasticity Selectively Mediated by Biomolecules
| العنوان: | An Aqueous Electrolyte Gated Artificial Synapse with Synaptic Plasticity Selectively Mediated by Biomolecules |
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| المؤلفون: | Xu, Xinzhao, Zhang, Haoqin, Shao, Lin, Ma, Rong, Guo, Meng, Liu, Yunqi, Zhao, Yan |
| المساهمون: | Ministry of Science and Technology of the People's Republic of China, National Natural Science Foundation of China, Natural Science Foundation of Shanghai, Postdoctoral Research Foundation of China |
| المصدر: | Angewandte Chemie International Edition ; volume 62, issue 29 ; ISSN 1433-7851 1521-3773 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The emulation of functions and behaviors of biological synapses using electronic devices has inspired the development of artificial neural networks (ANNs) in biomedical interfaces. Despite the achievements, artificial synapses that can be selectively responsive to non‐electroactive biomolecules and directly operate in biological environments are still lacking. Herein, we report an artificial synapse based on organic electrochemical transistors and investigate the selective modulation of its synaptic plasticity by glucose. The enzymatic reaction between glucose and glucose oxidase results in long‐term modulation of the channel conductance, mimicking selective binding of biomolecules to their receptors and consequent long‐term modulation of the synaptic weight. Moreover, the device shows enhanced synaptic behaviors in the blood serum at a higher glucose concentration, which suggests its potential application in vivo as artificial neurons. This work provides a step towards the fabrication of ANNs with synaptic plasticity selectively mediated by biomolecules for neuro‐prosthetics and human‐machine interfaces. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/anie.202302723 |
| الاتاحة: | http://dx.doi.org/10.1002/anie.202302723 https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202302723 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.AB9479B8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/anie.202302723 |
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