Academic Journal
Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study
| العنوان: | Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study |
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| المؤلفون: | Rolandi, E., Dodich, A., Galluzzi, S., Ferrari, C., Mandelli, S., Ribaldi, F., Munaretto, G., Ambrosi, C., Gasparotti, R., Violi, D., Canessa, N., Iannaccone, S., Marcone, A., Falini, A., Hampel, H., Frisoni, G. B., Cerami, C., Cavedo, E. |
| المساهمون: | Rolandi E., Dodich A., Galluzzi S., Ferrari C., Mandelli S., Ribaldi F., Munaretto G., Ambrosi C., Gasparotti R., Violi D., Canessa N., Iannaccone S., Marcone A., Falini A., Hampel H., Frisoni G. B., Cerami C., Cavedo E. |
| سنة النشر: | 2020 |
| المجموعة: | Università degli Studi di Brescia: OPENBS - Open Archive UniBS |
| مصطلحات موضوعية: | Aged Brain/physiopathology Dementia/physiopathology/*therapy Exercise Female Humans Life Style Magnetic Resonance Imaging Male *Memory Memory Disorders/physiopathology/*therapy Middle Aged Alzheimer’s disease Neuroimaging Non-pharmacologic interventions Primary prevention Subjective cognitive decline |
| الوصف: | BACKGROUND: Alzheimer's Disease (AD) is a multifactorial disorder driven by genetic and modifiable lifestyle risk factors. Lifestyle primary prevention initiatives may reduce the prevalence and incidence of dementia in older adults. OBJECTIVES: The E.Mu.N.I study is a randomized controlled trial investigating the effect of multilevel non-pharmacologic interventions on cognitive performances (primary outcome) and structural and vascular brain MRI markers (secondary outcome), as well as markers of brain functional connectivity change (exploratory outcome), in older adults with subjective memory decline (SMD). Here, we present the study design and the baseline features of the sample. METHODS: Cognitively intact older adults with SMD, enrolled between February 2016 and June 2017, were randomly assigned to one of the 3 interventions for 1 year: Active Control Intervention (ACI), i.e., educational lessons; Partial Intervention (PI), i.e., homotaurine administration (100 mg/die) and lessons on the Mediterranean diet; Multilevel Intervention (MI), i.e., PI plus computerized cognitive training and physical exercise training. RESULTS: One-hundred and twenty-eight eligible participants were enrolled (66% female; age: 68 ± 5 years). Eighty-two percent of the sample was composed of volunteers with SMD from the community. Participants were randomly allocated to the interventions as follows: ACI (N = 40), PI (N = 44), MI (N = 44). No significant differences among groups emerged on socio-demographic, clinical-neuropsychological variables and MRI markers at baseline. CONCLUSIONS: The outcomes obtained from the E.Mu.N.I. study will clarify the efficacy of multilevel non-pharmacologic interventions on cognitive and neuroimaging markers in SMD individuals. This is a crucial step forward for the development of cost-effective non-pharmacologic primary prevention initiatives for AD. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31749018; info:eu-repo/semantics/altIdentifier/wos/WOS:000529543100007; volume:32; issue:5; firstpage:817; lastpage:826; numberofpages:10; journal:AGING CLINICAL AND EXPERIMENTAL RESEARCH; https://hdl.handle.net/11379/574899; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85075335052 |
| DOI: | 10.1007/s40520-019-01403-3 |
| الاتاحة: | https://hdl.handle.net/11379/574899 https://doi.org/10.1007/s40520-019-01403-3 |
| رقم الانضمام: | edsbas.AB428880 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s40520-019-01403-3 |
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