Academic Journal
Investigating Parkinson’s disease risk across farming activities using data mining and large-scale administrative health data
| العنوان: | Investigating Parkinson’s disease risk across farming activities using data mining and large-scale administrative health data |
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| المؤلفون: | Petit, Pascal, Berger, François, Bonneterre, Vincent, Vuillerme, Nicolas |
| المساهمون: | Autonomie, Gérontologie, E-santé, Imagerie & Société Grenoble (AGEIS), Université Grenoble Alpes (UGA), BrainTech Laboratory CHU Grenoble Alpes - Inserm U1205 (Brain Tech Lab), Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Environnement et Prévention en Santé des Populations (TIMC-EPSP), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP), Centre de ressources de pathologie professionnelle et environnementale - CHUGA (CRPPE - AuRA), Institut universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-19-P3IA-0003,MIAI,MIAI @ Grenoble Alpes(2019), ANR-10-AIRT-0005,NANOELEC,NANOELEC(2010), ANR-15-IDEX-0002,UGA,IDEX UGA(2015) |
| المصدر: | EISSN: 2373-8057 ; npj Parkinson's Disease ; https://hal.science/hal-04874259 ; npj Parkinson's Disease, 2025, 11, pp.13. ⟨10.1038/s41531-024-00864-2⟩ |
| بيانات النشر: | CCSD Nature |
| سنة النشر: | 2025 |
| مصطلحات موضوعية: | Digital public health, Farming exposome, Agricultural exposome, Administrative health database, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| الوصف: | International audience ; The risk of Parkinson's disease (PD) associated with farming has received considerable attention, in particular for pesticide exposure. However, data on PD risk associated with specific farming activities is lacking. We aimed to explore whether specific farming activities exhibited a higher risk of PD than others among the entire French farm manager (FM) population. A secondary analysis of real-world administrative insurance claim data and electronic health/medical records (TRACTOR project) was conducted to estimate PD risk for 26 farming activities using data mining. PD cases were identified through chronic disease declarations and antiparkinsonian drug claims. There were 8845 PD cases among 1,088,561 FMs. The highest-risk group included FMs engaged in pig farming, cattle farming, truck farming, fruit arboriculture, and crop farming, with mean hazard ratios (HRs) ranging from 1.22 to 1.67. The lowest-risk group included all activities involving horses and small animals, as well as gardening, landscaping and reforestation companies (mean HRs: 0.48-0.81). Our findings represent a preliminary work that suggests the potential involvement of occupational risk factors related to farming in PD onset and development. Future research focusing on farmers engaged in high-risk farming activities will allow to uncover potential occupational factors by better characterizing the farming exposome, which could improve PD surveillance among farmers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41531-024-00864-2 |
| الاتاحة: | https://hal.science/hal-04874259 https://hal.science/hal-04874259v1/document https://hal.science/hal-04874259v1/file/Petit_et_al-2025-npj_Parkinson%27s_Disease.pdf https://doi.org/10.1038/s41531-024-00864-2 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.AB2ADF1E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41531-024-00864-2 |
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