Academic Journal
Viral load undetectable state and predictors among children and adolescents living with HIV in South Gondar, Ethiopia, 2023: an 8-year retrospective cohort study
| العنوان: | Viral load undetectable state and predictors among children and adolescents living with HIV in South Gondar, Ethiopia, 2023: an 8-year retrospective cohort study |
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| المؤلفون: | Chanie, Ermias Sisay, Feleke, Dejen Getaneh, Emiru, Tigabu Desie, Abuhay, Abere Gebru, Hailemeskel, Habtamu Shimels, Baye, Astewle Andargie, Bantie, Berihun, Amare, Abraham Tsedalu, Nega, Tadila Dires, Anley, Denekew Tenaw, Dessie, Anteneh Mengist, Asnakew, Sintayehu, Moges, Natnael, Kassahun, Wubet Muluye, Diress, Mitiku Arayaw, Asfaw, Abeje Kumlachew, Ferede, Dawit Alemu, Wondifraw, Endalk Birrie, Jimma, Melkamu Senbeta, GebreEyesus, Fisha Alebel, Chanie, Sewnet Sisay |
| المساهمون: | Debre Tabor University |
| المصدر: | BMJ Open ; volume 14, issue 10, page e083206 ; ISSN 2044-6055 2044-6055 |
| بيانات النشر: | BMJ |
| سنة النشر: | 2024 |
| الوصف: | Objectives The objective of this study is to examine the zonal-wide load undetectable state and predictors among children and adolescents living with HIV at South Gondar health institutions, 2023. Design A retrospective cohort study. Setting South Gondar Health Institutions, Northwest, Ethiopia. Participants We recruited 430 children and adolescents living with HIV who had a follow-up at the antiretroviral therapy (ART) clinic at health institutions from 1 June 2016 to 30 April 2023. Outcome measures The primary outcome measure of this study was the viral load undetectable state estimation. Moreover, the study assessed the median time viral load undetectable state and its predictors by the Cox-proportional hazard model. Data were entered into Epi-data V.4.2 and exported to STATA V.17 statistical software for analysis. Results The mean follow-up period was 8.5 (95% CI 8.1 to 8.9)±4.4 SD months, overall yielding 9151 person-month observations. At the end of the follow-up, 369 (85.8%, 95% CI 82.6% to 88.8%) of the children and adolescents achieved the viral load undetected state. Moreover, the overall median survival time to develop viral load undetectable state was found to be 6 months. The viral load undetected state in children and adolescents who have a cluster of differentiation 4 (CD4) count above the threshold level was 2.8 times higher than those in children and adolescents with a CD4 count lower than the threshold level (adjusted HR (AHR) 2.8 (95% CI 1.5, 5.3)). Likewise, the viral load undetected state in children and adolescents who have a good level of ART adherence was 2.0 times higher than those children and adolescents with a fair/poor level of ART adherence (AHR 2.0 (95% CI 1.1, 3.9)). Moreover, children and adolescents who had nutritional status ≥−2 Z score increased a viral load undetected state by 2.3 times as compared with children and adolescents with nutritional status <−2 Z score (AHR 2.3 (95% CI 1.3, 4.0)). Furthermore, children and adolescents who had no treatment failure increased a ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1136/bmjopen-2023-083206 |
| الاتاحة: | http://dx.doi.org/10.1136/bmjopen-2023-083206 https://syndication.highwire.org/content/doi/10.1136/bmjopen-2023-083206 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.AB17B859 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmjopen-2023-083206 |
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