Academic Journal
X-Ray Nanothermometry of Nanoparticles in Tumor-Mimicking Tissues under Photothermia
| العنوان: | X-Ray Nanothermometry of Nanoparticles in Tumor-Mimicking Tissues under Photothermia |
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| المؤلفون: | López-Méndez, Rosalía, Reguera, Javier, Fromain, Alexandre, Serea, Esraa Samy Abu, Céspedes, Eva, Terán, Francisco José, Zheng, Fangyuan, Parente, Ana, Garcia, Miguel Angel, Fonda, Emiliano, Camarero de Diego, Julio, Wilhelm, Claire, Muñoz Noval, Álvaro, Espinosa, Ana |
| المساهمون: | UAM. Departamento de Física de la Materia Condensada |
| بيانات النشر: | John Wiley and Sons Inc |
| سنة النشر: | 2024 |
| المجموعة: | Universidad Autónoma de Madrid (UAM): Biblos-e Archivo |
| مصطلحات موضوعية: | Nanomedicines, nanothermal therapy, nanothermometry, photothermia, plasmonic nanoparticles, X-ray absorption spectroscopy, Física |
| الوصف: | Temperature plays a critical role in regulating body mechanisms and indicating inflammatory processes. Local temperature increments above 42 °C are shown to kill cancer cells in tumorous tissue, leading to the development of nanoparticle-mediated thermo-therapeutic strategies for fighting oncological diseases. Remarkably, these therapeutic effects can occur without macroscopic temperature rise, suggesting localized nanoparticle heating, and minimizing side effects on healthy tissues. Nanothermometry has received considerable attention as a means of developing nanothermosensing approaches to monitor the temperature at the core of nanoparticle atoms inside cells. In this study, a label-free, direct, and universal nanoscale thermometry is proposed to monitor the thermal processes of nanoparticles under photoexcitation in the tumor environment. Gold-iron oxide nanohybrids are utilized as multifunctional photothermal agents internalized in a 3D tumor model of glioblastoma that mimics the in vivo scenario. The local temperature under near-infrared photo-excitation is monitored by X-ray absorption spectroscopy (XAS) at the Au L3-edge (11 919 eV) to obtain their temperature in cells, deepening the knowledge of nanothermal tumor treatments. This nanothermometric approach demonstrates its potential in detecting high nanothermal changes in tumor-mimicking tissues. It offers a notable advantage by enabling thermal sensing of any element, effectively transforming any material into a nanothermometer within biological environments ; This work was supported by the Comunidad de Madrid (2018-T1/IND-1005 (A.E.), 2018-T1/IND-10360, 2022–5A/IND-24234 (A.M-N.), ASAP-CM S2022/BMD-7434 (A.E.) and NanoMagCOST CMS2018/NMT-4321 (J.C.) projects), MICINN (FPI PRE2020-96246 grant (R.L-M.), PID2021-127033OB-C21 (A.E.), RYC2020-029282-I (A.E.), PID2021-126323OA-I00 (A.M-N), PID2019-106099RB-C43 AEI/10.13039/501100011033 (J.R.) projects and CSIC (PIE-20226AT024 (A.E.)). IMDEA Nanociencia acknowledges the “Severo Ochoa” program for Centres of ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-2-02-112632-7 2-02-112632-3 |
| تدمد: | 2192-2640 |
| Relation: | Advanced Healthcare Materials; https://doi.org/10.1002/adhm.202301863; Gobierno de España. FPI PRE2020-96246; Gobierno de España. PID2021- 127033OB-C21; Gobierno de España. PID2021-126323OA-100; Gobierno de España. PID2019-106099RB-C43; Gobierno de España. SEV-2016-0686; Gobierno de España. CEX2020-001039-S; Comunidad de Madrid. 2018-T1/IND-1005; Comunidad de Madrid. 2018-T1/IND-10360; Comunidad de Madrid. 2022–5A/IND-24234; Comunidad de Madrid. S2022/BMD-7434; Comunidad de Madrid. S2018/NMT-4321/NANOMAGCOST-CM; Advanced Healthcare Materials 12.31 (2023): 2301863; http://hdl.handle.net/10486/714159; 2301863-1; 31; 2301863-10; 12 |
| DOI: | 10.1002/adhm.202301863 |
| الاتاحة: | http://hdl.handle.net/10486/714159 https://doi.org/10.1002/adhm.202301863 |
| Rights: | © 2023 The Authors ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; Reconocimiento – NoComercial – SinObraDerivada ; openAccess |
| رقم الانضمام: | edsbas.AB177778 |
| قاعدة البيانات: | BASE |
| ردمك: | 9782021126327 2021126323 |
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| تدمد: | 21922640 |
| DOI: | 10.1002/adhm.202301863 |