Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

التفاصيل البيبلوغرافية
العنوان:	Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma
المؤلفون:	Khor, Chiea Chuen, Do, Tan, Jia, Hongyan, Nakano, Masakazu, George, Ronnie, Abu Amero, Khaled, Duvesh, Roopam, Chen, Li Jia, Li, Zheng, Nongpiur, Monisha E, Perera, Shamira A, Qiao, Chunyan, Wong, Hon Tym, Sakai, Hiroshi, De Melo, Mônica Barbosa, Lee, Mei Chin, Schan, Anita, Azhany, Yaakub, Dao, Thi Lam Huong, Ikeda, Yoko, Perez Grossmann, Rodolfo A, Zarnowski, Tomasz, Day, Alexander C, Jonas, Jost B, Tam, Pancy O. S., Tran, Tuan Anh, Ayub, Humaira, Akhtar, Farah, Micheal, Shazia, Chew, Paul T. K., Aljasim, Leyla A, Dada, Tanuj, Luu, Tam Thi, Awadalla, Mona S., Kitnarong, Naris, Wanichwecharungruang, Boonsong, Aung, Yee Yee, Mohamed Noor, Jelinar, Vijayan, Saravanan, Sarangapani, Sripriya, Husain, Rahat, Jap, Aliza, Baskaran, Mani, Goh, David, Su, Daniel H, Wang, Huaizhou, Yong, Vernon K, Yip, Leonard W, Trinh, Tuyet Bach, Makornwattana, Manchima, Nguyen, Thanh Thu, Leuenberger, Edgar U, Park, Ki Ho, Wiyogo, Widya Artini, Skumar, Rajesh, Tello, Celso, Kurimoto, Yasuo, Thapa, Suman S., Pathanapitoon, Kessara, Salmon, John F, Sohn, Yong Ho, Fea, Antonio, Ozaki, Mineo, Lai, Jimmy S. M., Tantisevi, Visanee, Khaing, Chaw Chaw, Mizoguchi, Takanori, Nakano, Satoko, Kim, Chan Yun, Tang, Guangxian, Fan, Sujie, Wu, Renyi, Meng, Hailin, Nguyen, Thi Thuy Giang, Tran, Tien Dat, Ueno, Morio, Martinez, Jose Maria, Ramli, Norlina, Aung, Yin Mon, Reyes, Rigo Daniel, Vernon, Stephen A, Fang, Seng Kheong, Xie, Zhicheng, Chen, Xiao Yin, Foo, Jia Nee, Sim, Kar Seng, Wong, Tina T., Quek, Desmond T, Venkatesh, Rengaraj, Kavitha, Srinivasan, Krishnadas, Subbiah R, Soumittra, Nagaswamy, Shantha, Balekudaru, Lim, Boon Ang, Ogle, Jeanne, Vasconcellos, José P. Cde, Costa, Vital P, Abe, Ricardo Y, De Souza, Bruno B, Sng, Chelvin C, Aquino, Maria C, Kosior Jarecka, Ewa, Fong, Guillermo Barreto, Tamanaja, Vania Castro, Fujita, Ricardo, Jiang, Yuzhen, Waseem, Naushin, Low, Sancy, Pham, Huan Nguyen, Al Shahwan, Sami, Craven, Erandy, Khan, Muhammad Imran, Dada, Rrima, Mohanty, Kuldeep, Faiq, Muneeb A, Whewitt, Alex, Burdon, Kathryn P, Gan, Eng Hui, Prutthipongsit, Anuwat, Patthanathamrongkasem, Thipnapa, Tcatacutan, Mary Ann, Felarca, Irene R, Sliao, Chona, Rusmayani, Emma, Istiantoro, Vira Wardhana, Consolandi, Giulia, Pignata, Giulia, Lavia, Carlo, Rojanapongpun, Prin, Mangkornkanokpong, Lerprat, Chansangpetch, Sunee, Chan, Jonathan C. H., Choy, Bonnie N. K., Shum, Jennifer W. H., Than, Hlaing May, Oo, Khin Thida, Han, Aye Thi, Yong, Victor H, Ng, Xiao Yu, Goh, Shuang Ru, Chong, Yaan Fun, Hibberd, Martin L, Seielstad, Mark, Png, Eileen, Dunstan, Sarah J, Van Vinh Chau, Nguyen, Bei, Jinxin, Zeng, Yi Xin, Karkey, Abhilasha, Basnyat, Buddha, Pasutto, Francesca, Paoli, Daniela, FREZZOTTI, PAOLO, Wang, Jie Jin, Mitchell, Paul, Fingert, John H, Allingham, R. Rand, Hauser, Michael A, Lim, Soon Thye, Chew, Soo Hong, Ebstein, Richard P, Sakuntabhai, Anavaj, Park, Kyu Hyung, Ahn, Jeeyun, Boland, Greet, Snippe, Harm, Stead, Richard, Quino, Raquel, Zaw, Su Nyunt, Lukasik, Urszula, Shetty, Rohit, Zahari, Mimiwati, Bae, Hyoung Won, Oo, Nay Lin, Kubota, Toshiaki, Manassakorn, Anita, Ho, Wing Lau, Dallorto, Laura, Hwang, Young Hoon, Kiire, Christine A, Kuroda, Masako, Djamal, Zeiras Eka, Peregrino, Jovell Ian M., Ghosh, Arkasubhra, Jeoung, Jin Wook, Hoan, Tung S., Srisamran, Nuttamon, Sandragasu, Thayanithi, Set, Saw Htoo, Doan, Vi Huyen, Bhattacharya, Shomi S, Ho, Ching Lin, Tan, Donald T., Sihota, Ramanjit, Loon, Seng Chee, Mori, Kazuhiko, Kinoshita, Shigeru, Den Hollander, Anneke I, Qamar, Raheel, Wang, Ya Xing, Teo, Yik Y, Tai, E. Shyong, Hartleben Matkin, Curt, Lozano Giral, David, Saw, Seang Mei, Cheng, Ching Yu, Czenteno, Juan, Pang, Chi Pui, Bui, Huong T. T., Hee, Owen, Craig, Jamie E., Edward, Deepak P, Yonahara, Michiko, Neto, Jamil Miguel, Guevara Fujita, Maria L., Xu, Liang, Ritch, Robert, Liza Sharmini, Ahmad Tajudin, Wong, Tien Y, Al Obeidan, Saleh, Do, Nhu Hon, Sundaresan, Periasamy, Tham, Clement C., Foster, Paul J, Vijaya, Lingam, Tashiro, Kei, Vithana, Eranga N., Wang, Ningli, Aung, Tin
المساهمون:	Khor, Chiea Chuen, Do, Tan, Jia, Hongyan, Nakano, Masakazu, George, Ronnie, Abu Amero, Khaled, Duvesh, Roopam, Chen, Li Jia, Li, Zheng, Nongpiur, Monisha E, Perera, Shamira A, Qiao, Chunyan, Wong, Hon Tym, Sakai, Hiroshi, De Melo, Mônica Barbosa, Lee, Mei Chin, Schan, Anita, Azhany, Yaakub, Dao, Thi Lam Huong, Ikeda, Yoko, Perez Grossmann, Rodolfo A, Zarnowski, Tomasz, Day, Alexander C, Jonas, Jost B, Tam, Pancy O. S., Tran, Tuan Anh, Ayub, Humaira, Akhtar, Farah, Micheal, Shazia, Chew, Paul T. K., Aljasim, Leyla A, Dada, Tanuj, Luu, Tam Thi, Awadalla, Mona S., Kitnarong, Nari, Wanichwecharungruang, Boonsong, Aung, Yee Yee, Mohamed Noor, Jelinar, Vijayan, Saravanan, Sarangapani, Sripriya, Husain, Rahat, Jap, Aliza, Baskaran, Mani, Goh, David, Su, Daniel H, Wang, Huaizhou, Yong, Vernon K, Yip, Leonard W, Trinh, Tuyet Bach, Makornwattana, Manchima, Nguyen, Thanh Thu, Leuenberger, Edgar U, Park, Ki Ho, Wiyogo, Widya Artini, Skumar, Rajesh, Tello, Celso, Kurimoto, Yasuo, Thapa, Suman S., Pathanapitoon, Kessara, Salmon, John F, Sohn, Yong Ho, Fea, Antonio, Ozaki, Mineo, Lai, Jimmy S. M., Tantisevi, Visanee, Khaing, Chaw Chaw, Mizoguchi, Takanori, Nakano, Satoko, Kim, Chan Yun, Tang, Guangxian, Fan, Sujie, Wu, Renyi, Meng, Hailin, Nguyen, Thi Thuy Giang, Tran, Tien Dat, Ueno, Morio, Martinez, Jose Maria, Ramli, Norlina, Aung, Yin Mon, Reyes, Rigo Daniel, Vernon, Stephen A, Fang, Seng Kheong, Xie, Zhicheng, Chen, Xiao Yin, Foo, Jia Nee, Sim, Kar Seng, Wong, Tina T., Quek, Desmond T, Venkatesh, Rengaraj, Kavitha, Srinivasan, Krishnadas, Subbiah R, Soumittra, Nagaswamy, Shantha, Balekudaru, Lim, Boon Ang, Ogle, Jeanne, Vasconcellos, José P. Cde, Costa, Vital P, Abe, Ricardo Y, De Souza, Bruno B, Sng, Chelvin C
سنة النشر:	2016
المجموعة:	Università degli Studi di Siena: USiena air
مصطلحات موضوعية:	Genetics
الوصف:	Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10 -5), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10 -6), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10 -4), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10 -1), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10 -2). We also confirmed significant association at three previously described loci (P < 5 × 10 â'8 for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG. © 2016 Nature America, Inc.
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	STAMPA
اللغة:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/27064256; info:eu-repo/semantics/altIdentifier/wos/WOS:000374834100016; volume:48; issue:5; firstpage:556; lastpage:562; numberofpages:7; journal:NATURE GENETICS; http://hdl.handle.net/11365/999469; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84963502585; https://www.nature.com/articles/ng.3540
DOI:	10.1038/ng.3540
الاتاحة:	http://hdl.handle.net/11365/999469 https://doi.org/10.1038/ng.3540 https://www.nature.com/articles/ng.3540
Rights:	info:eu-repo/semantics/openAccess
رقم الانضمام:	edsbas.AAF7FF34
قاعدة البيانات:	BASE

View record in BASE

الوصف
DOI:	10.1038/ng.3540