Synthesis of 2‐(pyridylvinyl)chromen‐4‐ones and their N‐oxide analogs for assessment of their biological activities as anticancer agents
| العنوان: | Synthesis of 2‐(pyridylvinyl)chromen‐4‐ones and their N‐oxide analogs for assessment of their biological activities as anticancer agents |
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| المؤلفون: | Ding, Yu Chun, Chu, Yi‐Cheng, Chang, Chuan‐Hsin, Liang, Jia‐Hua, Chen, Jih‐Jung, Shih, Tzenge‐Lien |
| بيانات النشر: | Wiley Online Library |
| سنة النشر: | 2024 |
| المجموعة: | Tamkang University Institutional Repository (TKUIR) / 淡江大學機構典藏 |
| مصطلحات موضوعية: | aza‐2‐styrylchromones, human non‐small‐cell lung cancer cells, pyridine N‐oxides |
| الوصف: | 2-Styrylchromones have been shown to possess a broad spectrum of biological activities. Replacing the carbon atom in 2-styrylchromones with a nitrogen atom in the benzene rings forms 2-(pyridylvinyl)chromen-4-ones (aza-2-styrylchromones). We have synthesized a series of novel 2-(pyridylvinyl)chromen-4-ones and their pyridine N-oxides to evaluate them as potential anticancer agents against human non-small-cell lung cancer cells (A549). Among the 18 synthesized molecules, compounds 18 and 8a exhibited comparable inhibitory effects to 5-fluorouracil and showed no toxicity against normal cells. ; 補正完畢 ; USA |
| نوع الوثيقة: | other/unknown material |
| وصف الملف: | 104 bytes; text/html |
| اللغة: | English |
| Relation: | Arch. Pharm. 357(4); 1521-4184; 0365-6233; https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/125467; https://tkuir.lib.tku.edu.tw/dspace/bitstream/987654321/125467/1/index.html |
| DOI: | 10.1002/ardp.202300445 |
| الاتاحة: | https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/125467 https://doi.org/10.1002/ardp.202300445 https://tkuir.lib.tku.edu.tw/dspace/bitstream/987654321/125467/1/index.html |
| رقم الانضمام: | edsbas.AAE6E1CA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ardp.202300445 |
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