Academic Journal
Exocytosis of a complement component C3-like protein by tunicate hemocytes
| العنوان: | Exocytosis of a complement component C3-like protein by tunicate hemocytes |
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| المؤلفون: | Raftos, David A., Fabbro, Megan, Nair, Sham V. |
| المصدر: | Raftos , D A , Fabbro , M & Nair , S V 2004 , ' Exocytosis of a complement component C3-like protein by tunicate hemocytes ' , Developmental and Comparative Immunology , vol. 28 , no. 3 , pp. 181-190 . https://doi.org/10.1016/S0145-305X(03)00136-8 |
| سنة النشر: | 2004 |
| الوصف: | This study investigates the exocytic responses of invertebrate hemocytes to pathogen-associated antigens. It demonstrates that a homologue of complement component C3, a key defensive protein of the innate immune system, is expressed by phagocytic hemocytes (non-refractile vacuolated cells) of the tunicate, Styela plicata. C3-like molecules are localized in sub-cellular vesicles and are rapidly exocytosed after stimulation with bacterial, fungal or algal cell surface molecules. Signal transduction analysis indicated that the induced secretion of C3-like molecules is mediated by a G-protein dependent signaling pathway, which modulates tubulin microtubules. All of this evidence indicates that hemocytes can contribute to host defense responses by rapidly exocytosing C3-like proteins at sites of infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/S0145-305X(03)00136-8 |
| الاتاحة: | https://researchers.mq.edu.au/en/publications/a16807e1-39b6-4955-8cc8-963274cc388c https://doi.org/10.1016/S0145-305X(03)00136-8 http://www.scopus.com/inward/record.url?scp=0344552399&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.AAD17695 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S0145-305X(03)00136-8 |
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