Academic Journal
Neutrophil extracellular traps in the intestinal mucosa of Eimeria-infected animals
| العنوان: | Neutrophil extracellular traps in the intestinal mucosa of Eimeria-infected animals |
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| المؤلفون: | Tamara Muñoz-Caro, Liliana Machado Ribeiro da Silva, Zaída Rentería-Solis, Anja Taubert, Carlos Hermosilla |
| المصدر: | Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 4, Pp 301-307 (2016) |
| بيانات النشر: | Wolters Kluwer Medknow Publications |
| سنة النشر: | 2016 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Eimeria bovis, Eimeria arloingi, Neutrophil extracellular traps, Apicomplexa, Coccidiosis, Arctic medicine. Tropical medicine, RC955-962, Biology (General), QH301-705.5 |
| الوصف: | Objective: To investigate the presence of neutrophil extracellular traps (NETs) in vivo by analysing intestinal sections from experimentally Eimeria bovis- and naturally Eimeria arloingi-infected animals. Methods: Intestinal samples of Eimeria arloingi- and Eimeria bovis-infected animals were analysed by using immunohistochemical and fluorescence approach by using monoclonal antibodies. Results: Classical NET components were confirmed by co-localization of extracellular DNA being decorated with neutrophil elastase and histones in Eimeria-infected tissue samples. Here, extrusion of NETs was exclusively detected in intestinal polymorphonuclear neutrophils infiltrating Eimeria-infected sites. In vivo NETs were either found in close proximity or in direct contact to different Eimeria stages suggesting a stage-independent process. NETs were also found within the gut lumen driven by polymorphonuclear neutrophils that were contacting released oocysts. Conclusions: We postulate that NETs might play an important role in innate defence reactions in coccidiosis therefore significantly altering the outcome of infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-2-221-16911-7 2-221-16911-5 |
| تدمد: | 2221-1691 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2221169115309606; https://doaj.org/toc/2221-1691; https://doaj.org/article/3d02a1101e5848baba3ee95a1fef1b3e |
| DOI: | 10.1016/j.apjtb.2016.01.001 |
| الاتاحة: | https://doi.org/10.1016/j.apjtb.2016.01.001 https://doaj.org/article/3d02a1101e5848baba3ee95a1fef1b3e |
| رقم الانضمام: | edsbas.AACFEBB0 |
| قاعدة البيانات: | BASE |
| ردمك: | 9782221169117 2221169115 |
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| تدمد: | 22211691 |
| DOI: | 10.1016/j.apjtb.2016.01.001 |