Academic Journal
The effect of infant vitamin B 12 supplementation on neurodevelopment: a follow-up of a randomised placebo-controlled trial in Nepal
| العنوان: | The effect of infant vitamin B 12 supplementation on neurodevelopment: a follow-up of a randomised placebo-controlled trial in Nepal |
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| المؤلفون: | Ulak, Manjeswori, Kvestad, Ingrid, Chandyo, Ram Krishna, Ranjitkar, Suman, Hysing, Mari, Schwinger, Catherine, Shrestha, Merina, Basnet, Sudha, Shrestha, Laxman P., Strand, Tor A. |
| المصدر: | British Journal of Nutrition ; volume 129, issue 1, page 41-48 ; ISSN 0007-1145 1475-2662 |
| بيانات النشر: | Cambridge University Press (CUP) |
| سنة النشر: | 2022 |
| الوصف: | The most critical period for brain development is before a child’s second birthday. Standardised tests measuring neurodevelopment are more reliable when administered after this period. Severe vitamin B 12 deficiency affects brain development and function. In a randomised, double-blind, placebo-controlled trial in 600 Nepalese infants (6–11 months at enrolment), we found no effect of 2 µg vitamin B 12 daily for a year on neurodevelopment. The primary objective of the current study was to measure the effect of the intervention on the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) full scale intelligence quotient (FSIQ). We measured the effect on the Bayley Scales of Infant and Toddler Development 3rd edition at age 30–35 months ( n 555). At age 42–47 months ( n 533), we used the WPPSI-IV and subtests from the Neuropsychological Assessment, 2nd edition (NEPSY-II). We also used the FSIQ to estimate subgroup specific effects. The mean ( sd ) WPPSI-IV FSIQ in the vitamin B 12 group was 84·4 (8·4) and 85·0 (8·6) in the placebo group (mean difference −0·5 (95 % CI -1·97, 0·94), P = 0·48). There were no effect of the vitamin B 12 on any of the other neurodevelopmental outcomes and no beneficial effect in any of the subgroups. In conclusion, providing 2 µg of vitamin B 12 for a year in infants at risk of vitamin B 12 deficiency does not improve preschool cognitive function. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1017/s0007114522000071 |
| الاتاحة: | https://doi.org/10.1017/s0007114522000071 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114522000071 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.AAAE5676 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1017/s0007114522000071 |
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