Academic Journal
Strategies for drug repurposing against coronavirus targets
| العنوان: | Strategies for drug repurposing against coronavirus targets |
|---|---|
| المؤلفون: | Smith, Poppy O, Jin, Peiqin, Rahman, Khondaker Miraz |
| المصدر: | Current Research in Pharmacology and Drug Discovery , 3 , Article 100072. (2022) |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Coronavirus, SARS-CoV-2, Drug repurposing, In silico screening |
| الوصف: | Repurposing regulatory agency approved drugs and investigational compounds with known safety profiles can significantly fast track the drug development timeline over de novo drug discovery, with lower investment requirements and improved attrition rate. These advantages are vital in any epidemic or pandemic situation, where hospital beds are occupied by patients for whom there is no known treatment. Here we examine drug repurposing in the context of human coronaviruses, SARS-CoV, MERS-CoV, and, in particular, SARS-CoV-2, the virus currently causing a continued widespread pandemic with substantial impacts on public health and economy. The key druggable targets explored were those involved in viral entry, viral replication, and viral-induced ARDS, as well as viral proteases, with a focus on the strategy by which the drugs were repurposed. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10187152/1/1-s2.0-S2590257121000596-main.pdf; https://discovery.ucl.ac.uk/id/eprint/10187152/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10187152/1/1-s2.0-S2590257121000596-main.pdf https://discovery.ucl.ac.uk/id/eprint/10187152/ |
| Rights: | open |
| رقم الانضمام: | edsbas.AA9DE828 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |