Academic Journal
Eight-year outcomes for patients with aortic valve stenosis at low surgical risk randomized to transcatheter vs. surgical aortic valve replacement
| العنوان: | Eight-year outcomes for patients with aortic valve stenosis at low surgical risk randomized to transcatheter vs. surgical aortic valve replacement |
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| المؤلفون: | Jørgensen, Troels Højsgaard, Thyregod, Hans Gustav Hørsted, Ihlemann, Nikolaj, Nissen, Henrik, Petursson, Petur, Kjeldsen, Bo Juel, Steinbrüchel, Daniel Andreas, Olsen, Peter Skov, Søndergaard, Lars |
| المصدر: | Jørgensen , T H , Thyregod , H G H , Ihlemann , N , Nissen , H , Petursson , P , Kjeldsen , B J , Steinbrüchel , D A , Olsen , P S & Søndergaard , L 2021 , ' Eight-year outcomes for patients with aortic valve stenosis at low surgical risk randomized to transcatheter vs. surgical aortic valve replacement ' , European Heart Journal , vol. 42 , no. 30 , pp. 2912-2919 . https://doi.org/10.1093/eurheartj/ehab375 |
| سنة النشر: | 2021 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | Bioprosthetic aortic valve durability, Mortality, Stroke, Surgical aortic valve replacement, Transcatheter aortic valve implantation |
| الوصف: | Aims: The aims of the study were to compare clinical outcomes and valve durability after 8 years of follow-up in patients with symptomatic severe aortic valve stenosis at low surgical risk treated with either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR). Methods and results: In the NOTION trial, patients with symptomatic severe aortic valve stenosis were randomized to TAVI or SAVR. Clinical status, echocardiography, structural valve deterioration, and failure were assessed using standardized definitions. In total, 280 patients were randomized to TAVI (n = 145) or SAVR (n = 135). Baseline characteristics were similar, including mean age of 79.1 ± 4.8 years and a mean STS score of 3.0 ± 1.7%. At 8-year follow-up, the estimated risk of the composite outcome of all-cause mortality, stroke, or myocardial infarction was 54.5% after TAVI and 54.8% after SAVR (P = 0.94). The estimated risks for all-cause mortality (51.8% vs. 52.6%; P = 0.90), stroke (8.3% vs. 9.1%; P = 0.90), or myocardial infarction (6.2% vs. 3.8%; P = 0.33) were similar after TAVI and SAVR. The risk of structural valve deterioration was lower after TAVI than after SAVR (13.9% vs. 28.3%; P = 0.0017), whereas the risk of bioprosthetic valve failure was similar (8.7% vs. 10.5%; P = 0.61). Conclusions: In patients with severe aortic valve stenosis at low surgical risk randomized to TAVI or SAVR, there were no significant differences in the risk for all-cause mortality, stroke, or myocardial infarction, as well as the risk of bioprosthetic valve failure after 8 years of follow-up. Clinical trial registration: URL: http://www.ClinicalTrials.gov. Unique identifier: NCT01057173. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1093/eurheartj/ehab375 |
| الاتاحة: | https://portal.findresearcher.sdu.dk/da/publications/6c56c84e-7682-48da-911d-1104aea19a91 https://doi.org/10.1093/eurheartj/ehab375 https://findresearcher.sdu.dk/ws/files/191356630/ehab375.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AA757A32 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/eurheartj/ehab375 |
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