Academic Journal
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors
| العنوان: | 4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors |
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| المؤلفون: | BARUCHELLO, Riccardo, SIMONI, Daniele, MARCHETTI, Paolo, RONDANIN, Riccardo, MANGIOLA, Stefania, COSTANTINI, Cristiana, M. Meli, G. Giannini, L. Vesci, V. Carollo, T. Brunetti, G. Battistuzzi, M. Tolomeo, W. Cabri |
| المساهمون: | Baruchello, Riccardo, Simoni, Daniele, Marchetti, Paolo, Rondanin, Riccardo, Mangiola, Stefania, Costantini, Cristiana, M., Meli, G., Giannini, L., Vesci, V., Carollo, T., Brunetti, G., Battistuzzi, M., Tolomeo, W., Cabri |
| سنة النشر: | 2014 |
| المجموعة: | Università degli Studi di Ferrara: CINECA IRIS |
| مصطلحات موضوعية: | 4 5 6 7-Tetrahydro-isoxazolo-[4 5-c]-pyridine, Anti-cancer drug, Heat shock protein 90 |
| الوصف: | Hsp90 is considered an interesting therapeutic target for anticancer drug development. Here we describe a new class of 4,5,6,7-tetrahydro-isoxazolo-[4,5-c]-pyridine compounds. A small library of derivatives has been synthesized and investigated. Some reported compounds show interesting properties combining both notable binding to Hsp90 and potent cell growth inhibitory activity. N-5 substitution with a 2,4 resorcinol carboxamide appears crucial for activity. Moreover, a derivative bearing a hydroxamic acid residue bound to C-3 amide portion was found to inhibit both Hsp90 and HDAC6. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000335487400006; volume:76; firstpage:53; lastpage:60; numberofpages:8; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11392/2121014; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84896702711; http://dx.doi.org/10.1016/j.ejmech.2014.01.056 |
| DOI: | 10.1016/j.ejmech.2014.01.056 |
| الاتاحة: | http://hdl.handle.net/11392/2121014 https://doi.org/10.1016/j.ejmech.2014.01.056 |
| رقم الانضمام: | edsbas.AA5B07D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejmech.2014.01.056 |
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