Academic Journal
A.F.: Loss of heterozygosity in benign breast epithelium in relation to breast cancer risk
| العنوان: | A.F.: Loss of heterozygosity in benign breast epithelium in relation to breast cancer risk |
|---|---|
| المؤلفون: | David M. Euhus, Leslie Cler, Narayan Shivapurkar Sara, George N. Peters, A. Marilyn Leitch, Shashank Heda, Adi F. Gazdar |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://jnci.oxfordjournals.org/content/94/11/858.full.pdf. |
| سنة النشر: | 2002 |
| المجموعة: | CiteSeerX |
| الوصف: | The multistage model of breast carci-nogenesis suggests that errors in DNA replication and repair generate diver-sity in the breast epithelium (the mu-tator phenotype), resulting in selec-tion and expansion of premalignant clones with an acquired survival ad-vantage. We measured loss of hetero-zygosity (LOH) in breast epithelial cells obtained by random fine-needle aspiration (FNA) biopsy from 30 asymptomatic women whose risk of breast cancer had been defined by the Gail model. Polymorphic microsatel-lite markers were selected on the basis of their relevance to breast cancer. Breast epithelium of 11 (37%) of 30 women had normal cytology, and that of 19 (63%) had proliferative cytology (eight with atypia and 11 without atypia). LOH was detected in two women with normal cytology and in 14 women (seven with atypia and seven without atypia) with prolifera-tive cytology (P =.007). The fre-quency of LOH was associated with the cytological diagnosis, as well. The mean proportion (range) of informa-tive markers demonstrating LOH was 0.02 (0–0.20) for the 11 women with normal cytology, as compared with 0.15 (0–0.50) for the 19 women with proliferative cytology (P =.02). Mean lifetime risk for developing breast cancer, as calculated by the Gail model, was 16.7 % for women with no LOH compared with 22.9 % for women with any LOH (P =.05). These observations support a multistage model of breast carcinogenesis where the initiating events are those that re-sult in genomic instability. Accurate individualized breast cancer risk as-sessment may be possible based on molecular analysis of breast epitheli-al cells obtained by random FNA. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.546.6393; http://jnci.oxfordjournals.org/content/94/11/858.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.546.6393 http://jnci.oxfordjournals.org/content/94/11/858.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.AA542AFA |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |