Academic Journal
Serum Anticholinergic Activity: A Possible Peripheral Marker of the Anticholinergic Burden in the Central Nervous System in Alzheimer’s Disease
| العنوان: | Serum Anticholinergic Activity: A Possible Peripheral Marker of the Anticholinergic Burden in the Central Nervous System in Alzheimer’s Disease |
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| المؤلفون: | Koji Hori, Kimiko Konishi, Masayuki Tani, Hiroi Tomioka, Ryo Akita, Yuka Kitajima, Mari Aoki, Sachiko Yokoyama, Kazunari Azuma, Daisuke Ikuse, Norihisa Akashi, Misa Hosoi, Koichi Jinbo, Mitsugu Hachisu |
| المصدر: | Disease Markers, Vol 2014 (2014) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2014 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | We review the utility of serum anticholinergic activity (SAA) as a peripheral marker of anticholinergic activity (AA) in the central nervous system (CAA). We hypothesize that the compensatory mechanisms of the cholinergic system do not contribute to SAA if their system is intact and that if central cholinergic system deteriorates alone in conditions such as Alzheimer’s disease or Lewy body dementia, CAA and SAA are caused by way of hyperactivity of inflammatory system and SAA is a marker of the anticholinergic burden in CNS. Taking into account the diurnal variations in the plasma levels of corticosteroids, which are thought to affect SAA, it should be measured at noon or just afterward. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0278-0240 1875-8630 |
| Relation: | http://dx.doi.org/10.1155/2014/459013; https://doaj.org/toc/0278-0240; https://doaj.org/toc/1875-8630; https://doaj.org/article/d7ac91be08cf4189b52723461e6fb8ae |
| DOI: | 10.1155/2014/459013 |
| الاتاحة: | https://doi.org/10.1155/2014/459013 https://doaj.org/article/d7ac91be08cf4189b52723461e6fb8ae |
| رقم الانضمام: | edsbas.AA4C65CA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02780240 18758630 |
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| DOI: | 10.1155/2014/459013 |