Academic Journal
Evaluation of MR-safe bioptomes for MR-guided endomyocardial biopsy in minipigs: a potential radiation-free clinical approach
| العنوان: | Evaluation of MR-safe bioptomes for MR-guided endomyocardial biopsy in minipigs: a potential radiation-free clinical approach |
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| المؤلفون: | Svetlove, Angelika, Ritter, Christian O., Dullin, Christian, Schmid, Michael, Schauer, Senta, Uihlein, Johannes, Uecker, Martin, Mietsch, Matthias, Stadelmann, Christine, Lotz, Joachim, Unterberg-Buchwald, Christina |
| المساهمون: | Svetlove, Angelika, Ritter, Christian O., Dullin, Christian, Schmid, Michael, Schauer, Senta, Uihlein, Johannes, Uecker, Martin, Mietsch, Matthias, Stadelmann, Christine, Lotz, Joachim, Unterberg-Buchwald, Christina |
| سنة النشر: | 2023 |
| المجموعة: | Georg-August-Universität Göttingen: GoeScholar |
| مصطلحات موضوعية: | Biopsy, Magnetic resonance imaging (interventional), Synchrotrons, X-ray microtomography |
| الوصف: | Background Diagnostic accuracy of endomyocardial biopsy could improve if clinically safe magnetic resonance (MR)-compatible bioptomes were available. We explored two novel MR-compatible cardiac bioptomes for performance, safety, and clinical viability, employing in vivo minipig trials and phase-contrast synchrotron radiation computed microtomography (SRµCT). Methods Analysis of ex vivo obtained pig endomyocardial biopsies was performed using phase-contrast SRµCT and conventional two-dimensional histology. The technical performance was evaluated by measuring volume, inner and outer integrities, compression, and histological diagnostic value in 3 sets (6 per set) of biopsies for each experimental bioptome. The bioptomes were tested in vivo in 3 healthy minipigs per bioptome. The clinical feasibility was evaluated by procedural and cutting success as well as histological diagnostic value. Results The bioptome with the ‘grind-grind’ design achieved similar values to control in compression (p = 0.822), inner (p = 0.628), and outer (p = 0.507), integrities ex vivo. It showed a better performance in the in vivo real-time MRI setting demonstrating a higher cutting success (91.7%) than the ‘grind-anvil’ (86.2%) design. In both ex vivo and in vivo evaluations, the ‘grind-grind’ design displayed sufficient diagnostic value (83% and 95%). The ‘grind-anvil’ design showed adequate diagnostic value both ex vivo and in vivo (78% and 87.5%) but was not comparable to control according to the three-dimensional (3D) analysis. Conclusion A novel MR-compatible bioptome was identified as plausible in a clinical setting. Additionally, SRµCT and subsequent 3D structural analysis could be valuable in the label-free investigation of myocardial tissue at a micrometer level. Relevance statement Implementation of MR-guided biopsy can improve animal studies on structural myocardial changes at any point in an experimental setup. With further improvements in guiding catheters, MR-guided biopsy, using the new bioptome, has a potential ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | EXC 2067: Multiscale Bioimaging; European Radiology Experimental. 2023 Dec 05;7(1):76; https://resolver.sub.uni-goettingen.de/purl?gro-2/139388; https://mbexc.uni-goettingen.de/literature/publications/791 |
| DOI: | 10.1186/s41747-023-00391-4 |
| الاتاحة: | https://resolver.sub.uni-goettingen.de/purl?gro-2/139388 https://doi.org/10.1186/s41747-023-00391-4 https://mbexc.uni-goettingen.de/literature/publications/791 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; The Author(s) |
| رقم الانضمام: | edsbas.AA3E5FBC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s41747-023-00391-4 |
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