Academic Journal
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
| العنوان: | Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality |
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| المؤلفون: | Mast, Fred D., Navare, Arti T., van der Sloot, Almer M., Coulombe-Huntington, Jasmin, Rout, Michael P., Baliga, Nitin S., Kaushansky, Alexis, Chait, Brian T., Aderem, Alan, Rice, Charles M., Sali, Andrej, Tyers, Mike, Aitchison, John D. |
| المساهمون: | National Institutes of Health, Canadian Institutes for Health Research, G. Harold and Leila Y. Mathers Charitable Foundation, George Mason University |
| المصدر: | Journal of Cell Biology ; volume 219, issue 10 ; ISSN 0021-9525 1540-8140 |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2020 |
| الوصف: | With the rapid global spread of SARS-CoV-2, we have become acutely aware of the inadequacies of our ability to respond to viral epidemics. Although disrupting the viral life cycle is critical for limiting viral spread and disease, it has proven challenging to develop targeted and selective therapeutics. Synthetic lethality offers a promising but largely unexploited strategy against infectious viral disease; as viruses infect cells, they abnormally alter the cell state, unwittingly exposing new vulnerabilities in the infected cell. Therefore, we propose that effective therapies can be developed to selectively target the virally reconfigured host cell networks that accompany altered cellular states to cripple the host cell that has been converted into a virus factory, thus disrupting the viral life cycle. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1083/jcb.202006159 |
| DOI: | 10.1083/jcb.202006159/1833588/jcb_202006159.pdf |
| الاتاحة: | http://dx.doi.org/10.1083/jcb.202006159 https://rupress.org/jcb/article-pdf/doi/10.1083/jcb.202006159/1833588/jcb_202006159.pdf |
| Rights: | http://www.rupress.org/terms/ ; https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| رقم الانضمام: | edsbas.A9DDBEA6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1083/jcb.202006159 |
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