Academic Journal
Evaluation of a Validated Luminex-Based Multiplex Immunoassay for Measuring Immunoglobulin G Antibodies in Serum to Pneumococcal Capsular Polysaccharides
| العنوان: | Evaluation of a Validated Luminex-Based Multiplex Immunoassay for Measuring Immunoglobulin G Antibodies in Serum to Pneumococcal Capsular Polysaccharides |
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| المؤلفون: | Tan, Charles Y., Immermann, Fred W., Sebastian, Shite, Pride, Michael W., Pavliakova, Danka, Belanger, Kelly A., Watson, Wendy, Scott, Daniel A., Sidhu, Mohinder, Jansen, Kathrin U., Giardina, Peter C. |
| المساهمون: | Wilkins, Patricia P., Pfizer |
| المصدر: | mSphere ; volume 3, issue 4 ; ISSN 2379-5042 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2018 |
| الوصف: | The pneumococcal enzyme-linked immunosorbent assay (ELISA) measures IgG antibodies in human serum, and it is an important assay that supports licensure of pneumococcal vaccines. The immune correlate of protection, 0.35 µg/ml of IgG antibodies, was determined by the ELISA method. Pfizer has developed a new Luminex-based assay platform to replace the ELISA. These papers describe the important work of (i) validating the Luminex-based assay and (ii) bridging the immune correlate of protection (0.35 µg/ml IgG) to equivalent values reported by the Luminex platform. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/msphere.00127-18 |
| DOI: | 10.1128/mSphere.00127-18 |
| الاتاحة: | http://dx.doi.org/10.1128/msphere.00127-18 https://journals.asm.org/doi/pdf/10.1128/mSphere.00127-18 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ ; https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.A9C233D9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/msphere.00127-18 |
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