Academic Journal
Evaluation the effect of testosterone on the number of endothelial progenitor cells and amount of SDF-1α, PDGF, bFGF, and NO
| العنوان: | Evaluation the effect of testosterone on the number of endothelial progenitor cells and amount of SDF-1α, PDGF, bFGF, and NO |
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| المؤلفون: | Maryam Motamer, Shaghayegh Haghjooy Javanmard, Zahra Sadat Mortazavi, Saeide Bahrani |
| المصدر: | International Journal of Preventive Medicine, Vol 10, Iss 1, Pp 214-214 (2019) |
| بيانات النشر: | Wolters Kluwer Medknow Publications |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | basic fibroblast growth factor, endothelial progenitor cell, nitric oxide, platelet-derived growth factor, stromal cell-derived factor-1α, testosterone, Medicine |
| الوصف: | Background: Recent therapeutic advances in cardiovascular disease, thanks to the discovery of endothelial progenitor cells (EPCs). Stromal cell-derived factor-1α (SDF-1α), platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), and nitric oxide (NO) play a role in migration, homing, and differentiation of EPCs into mature endothelial cells. The incidence of cardiovascular disease is higher in men than in women. This fact suggests the influence of sex hormones on incidence of cardiovascular disease. Methods: Twenty-four female wistar rats weighing 160–180 g were randomly divided into four groups (N = 6): 1. sham-treated by sesame oil, 2. ovariectomized (OVX)-treated by sesame oil, 3. OVX-treated by 10 μg/kg/day testosterone, and 4. OVX-treated by 100 μg/kg/day testosterone. After 21 days, the animals were euthanized and blood samples were saved for determination of EPC count and serum levels of SDF-1α, PDGF, bFGF, and NO production. Results: High-dose testosterone induced significant increase in EPC count in OVX rats (P < 0.05). Also 100 μg/kg/day testosterone increased serum level of SDF-1α more than OVX-treated by 10 μg/kg/day testosterone (P < 0.05). But 10 μg/kg/day testosterone increased significantly the serum level of PDGF >100 μg/kg/day testosterone-treated group (P < 0.05). The serum level of bFGF in sham-treated by sesame oil was equal with its concentration in OVX-treated by 100 μg/kg/day testosterone. And the serum concentration of NO production in testosterone-treated groups were significantly less than other groups (P < 0.05). Conclusions: This study suggests that testosterone might be effective on cardiovascular disease in females by increasing EPC count through SDF-1α and PDGF mechanisms which are some of the vascular healing factors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2008-7802 2008-8213 |
| Relation: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2019;volume=10;issue=1;spage=214;epage=214;aulast=Motamer; https://doaj.org/toc/2008-7802; https://doaj.org/toc/2008-8213; https://doaj.org/article/5b98137fe8e74217a968c4f5f0bb0cfe |
| DOI: | 10.4103/ijpvm.IJPVM_79_18 |
| الاتاحة: | https://doi.org/10.4103/ijpvm.IJPVM_79_18 https://doaj.org/article/5b98137fe8e74217a968c4f5f0bb0cfe |
| رقم الانضمام: | edsbas.A987160F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20087802 20088213 |
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| DOI: | 10.4103/ijpvm.IJPVM_79_18 |