Academic Journal
Potential roles of alzheimer precursor protein A4 and β-amyloid in survival and function of aged spinal motor neurons after axonal injury
| العنوان: | Potential roles of alzheimer precursor protein A4 and β-amyloid in survival and function of aged spinal motor neurons after axonal injury |
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| المؤلفون: | Wu, W, Xie, Y, Yao, Z, Chai, H, Wong, WM |
| بيانات النشر: | //www3.interscience.wiley.com/cgi-bin/jhome/34828 United States |
| سنة النشر: | 2003 |
| المجموعة: | University of Hong Kong: HKU Scholars Hub |
| مصطلحات موضوعية: | Aging - Pathology, Amyloid Beta-Peptides - Pharmacology, Amyloid Beta-Protein Precursor - Pharmacology, Animals, Axotomy - Methods, Cell Survival - Drug Effects - Physiology, Choline O-Acetyltransferase - Metabolism, Disease Models, Animal, Immunohistochemistry - Methods, Male, Motor Neurons - Drug Effects - Pathology, Radiculopathy - Metabolism - Pathology, Rats, Sprague-Dawley, Spinal Cord - Metabolism - Pathology, Spinal Injuries - Pathology, Time Factors |
| الوصف: | To study the potential role of Alzheimer precursor protein A4 (APP) and β-amyloid (A/β) on aging motor neuron survival, expression of APP, A/β, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury. Approximately 45% in number of total aged spinal motor neuron were normally APP-positive. A/β-positive neurites were observed normally in the spinal ventral horn of aged rats. After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury. In contrast, after avulsion, expression of APP and A/β were downregulated in the spinal ventral horn of aged rats, and marked loss of spinal motor neurons and downregulated ChaT expression were observed. Our data indicate that APP and A/β might play beneficial roles in neuronal survival of aged spinal motor neurons after axonal injury. © 2003 Wiley-Liss, Inc. ; link_to_subscribed_fulltext |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0360-4012 |
| Relation: | Journal of Neuroscience Research; http://www.scopus.com/mlt/select.url?eid=2-s2.0-0042172835&selection=ref&src=s&origin=recordpage; Journal Of Neuroscience Research, 2003, v. 73 n. 4, p. 557-564; 564; 85079; WOS:000184521000014; eid_2-s2.0-0042172835; 557; http://hdl.handle.net/10722/149619; 73 |
| DOI: | 10.1002/jnr.10667 |
| الاتاحة: | https://doi.org/10.1002/jnr.10667 http://hdl.handle.net/10722/149619 |
| رقم الانضمام: | edsbas.A97C02D3 |
| قاعدة البيانات: | BASE |
| تدمد: | 03604012 |
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| DOI: | 10.1002/jnr.10667 |