التفاصيل البيبلوغرافية
| العنوان: |
Combination of the Hematopoietic Cell Transplantation Comorbidity Index and the European Group for Blood and Marrow Transplantation Score Allows a Better Stratification of High-Risk Patients Undergoing Reduced-Toxicity Allogeneic Hematopoietic Cell Transplantation |
| المؤلفون: |
Barba, Pere, Martino Bofarull, Rodrigo, Pérez-Simón, José Antonio, Fernandez Aviles, Francesc, Castillo, Nerea, Piñana, José Luis, López-Anglada, LucÃa, Rovira Argelagués, Montserrat, Bosch Albareda, Francesc, Carreras, Enric, López Corral, LucÃa, Sierra, Jorge, Valcárcel, David, Universitat Autònoma de Barcelona. Departament de Medicina |
| سنة النشر: |
2014 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: |
Allo-reduced-intensity conditioning, Comorbidity, EBMT score, HCT-CI, Reduced-intensity conditioning stem cell transplantation |
| الوصف: |
This study was conducted to determine whether the integration of the Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) and the European Group for Blood and Marrow Transplantation (EBMT) score would improve individual capacity for stratification of high-risk HCT candidates. A total of 442 consecutive patients receiving an allogeneic HCT after reduced-toxicity conditioning was included. Final HCT-CI and EBMT scores were calculated and validated. Then, patients were grouped into a 6-category new combination model according to the HCT-CI (0, 1 to 2, ≥3) and EBMT scores (0 to 3, 4 to 7), and the model's predictive capacity was also evaluated. Median HCT-CI and EBMT scores were 3 and 4, respectively. Increased HCT-CI was associated with higher 4-year nonrelapse mortality (NRM) and lower 4-year overall survival (OS), whereas a high EBMT score was associated with higher 4-year NRM. The HCT-CI showed a trend for a better predictive capacity than the EBMT score (c-statistic.6 versus.54, P=1). According to the new model, patients within HCT-CI of 0 and HCT-CI of 1 to 2 groups had similar risk of NRM independently of their EBMT score. Within the HCT-CI ≥ 3 group, patients with low EBMT score showed lower NRM (25% versus 40%, P=04) and a trend to higher OS (52% versus 36%, P=06) than patients with a high EBMT score. Moreover, patients with HCT-CI ≥ 3 and EBMT score 0 to 3 had similar outcomes than those with HCT-CI of 1 to 2. In conclusion, the combination of HCT-CI and the EBMT score is feasible and might contribute to a better identification of high-risk patients, improving selection of best allogeneic HCT candidates. © 2014 American Society for Blood and Marrow Transplantation. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
15236536 |
| Relation: |
Ministerio de Ciencia e Innovación PI1100872; Ministerio de EconomÃa y Competitividad RD12/0036/0071; Fundació la Marató de TV3 100830/31/32; Biology of blood and marrow transplantation; Vol. 20 Núm. 1 (january 2014), p. 66-72; https://ddd.uab.cat/record/301845; urn:10.1016/j.bbmt.2013.10.011; urn:oai:ddd.uab.cat:301845; urn:scopus_id:84890933391; urn:articleid:15236536v20n1p66; urn:pmid:24141006 |
| الاتاحة: |
https://ddd.uab.cat/record/301845 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: |
edsbas.A9410D0A |
| قاعدة البيانات: |
BASE |
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