التفاصيل البيبلوغرافية
| العنوان: |
Low-dose exogenous FSH initiated during the early, mid or late follicular phase can induce multiple dominant follicle development |
| المؤلفون: |
Hohmann, F.P. (Femke), Laven, J.S.E. (Joop), Jong, F.H. (Frank) de, Eijkemans, M.J.C. (René), Fauser, B.C.J.M. (Bart) |
| المصدر: |
Human Reproduction |
| سنة النشر: |
2001 |
| المجموعة: |
RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: |
Follicular Phase, Adult, Body Mass Index, Chorionic Gonadotropin/administration & dosage, Estradiol/blood, Female, Follicle Stimulating Hormone/*administration & dosage/blood/pharmacokinetics, Humans, Inhibins/blood, Luteinizing Hormone/blood, Ovarian Follicle/*drug effects/*physiology/ultrasonography, Ovulation Induction, Prospective Studies, Recombinant Proteins/administration & dosage/pharmacokinetics, Research Support, Non-U.S. Gov't, Time Factors |
| الوصف: |
This prospective, randomized trial in normo-ovulatory women was designed to test whether administration of low-dose exogenous FSH initiated during the early, mid to late follicular phase can induce multiple dominant follicle development. Forty normal weight women (age 19-35 years, cycle length 25-32 days) participated. A fixed dose (75 IU/day) of recombinant FSH was started on either cycle day 3 (n = 13), 5 (n = 13) or 7 (n = 14) until the induction of ovulation with human chorionic gonadotrophin. Frequent transvaginal ultrasound scans and blood sampling were performed. Multifollicular growth occurred in all groups (overall in 60%), although day 7 starters showed less multifollicular growth. Age, cycle length and initial FSH and inhibin B concentrations were similar between subjects with single or multiple follicle development. However, for all women the lower the body mass index (BMI), the more follicles emerged (r = -0.44, P = 0.007). If multifollicular growth occurred, the length of the luteal phase was reduced (P = 0.002) and midluteal serum concentrations of LH (P = 0.03) and FSH (P = 0.004) were decreased and oestradiol (P = 0.002) and inhibin A (P = 0.01) were increased. In conclusion, interference with decremental serum FSH concentrations by administration of low dose FSH starting on cycle day 3, 5 or as late as day 7, is capable of disrupting |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
http://repub.eur.nl/pub/9631; urn:hdl:1765/9631 |
| الاتاحة: |
http://repub.eur.nl/pub/9631 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.A90654D5 |
| قاعدة البيانات: |
BASE |