Academic Journal
Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients
| العنوان: | Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients |
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| المؤلفون: | Aksu, K., Tunç, Åževket Ercan, Keser, G., Öksel, Fahrettin, DoÄŸanavÅŸargil, Eker, Pirildar, T., Turk, T. |
| سنة النشر: | 2005 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | P-selectin, Behçet's disease, Platelet-activating factor, Thrombosis, PADGEM protein, thrombocyte activating factor, article, Behcet disease, clinical article, clinical feature, comparative study, controlled study, correlation analysis, deep vein thrombosis, disease activity, endothelium injury, human, immunohistochemistry, leukocyte, lipid blood level, priority journal, protein function, statistical significance, vein thrombosis, Adult, Behcet Syndrome, Calcimycin, Cells, Cultured, Cross-Sectional Studies |
| الوصف: | Objective: The aim of this study was to compare plasma Platelet-activating factor (PAF) and P-selectin (CD62P) activities in Behçet's disease patients with and without thrombosis. Methods: In this cross-sectional and descriptive study, 30 consecutive Behçet's patients were included, 15 of them with venous thrombosis. All patients were also divided into two subgroups according to the presence or absence of clinical activity. Plasma PAF levels, basal and Ca++ ionophore (A23187)-induced leukocyte (cellular) PAF activities, and platelet-rich plasma ?CD62P activity (the mean fluorescent density difference between CD62P phycoerythrin-positive and -negative stains) were evaluated. Results: In the thrombotic group, plasma PAF (P=0.001), basal leukocyte PAF (P=0.017), induced leukocyte PAF (P=0.024), and ?CD62P (P=0.023) levels were significantly higher than in the nonthrombotic group. In the whole group of Behçet's patients, there was a positive correlation between plasma PAF and ?CD62P levels (r=0.533, P=0.002). When we compared clinically active and inactive patients with respect to the above parameters, there was no significant difference, irrespective of thrombosis. Plasma PAF (P=0.001), basal leukocyte PAF (P=0.004), and ?CD62P (P=0.038) levels were significantly higher in the presence of both clinical activity and thrombosis than of clinical activity alone. Conclusion: Platelet-activating factor and CD62P may contribute to endothelial injury and thrombosis development in Behçet's disease. These two parameters seem related to the presence of thrombosis rather than clinical activity. © Springer-Verlag 2004. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Rheumatology International; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/4847; 25; 326; 331; WOS:000229906100002 |
| DOI: | 10.1007/s00296-004-0450-4 |
| الاتاحة: | https://hdl.handle.net/11499/4847 https://doi.org/10.1007/s00296-004-0450-4 |
| Rights: | none |
| رقم الانضمام: | edsbas.A8F02EFE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00296-004-0450-4 |
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