Oral phytate supplementation on the progression of mild cognitive impairment, brain iron deposition and diabetic retinopathy in patients with type 2 diabetes: a concept paper for a randomized double blind placebo controlled trial (the PHYND trial)

التفاصيل البيبلوغرافية
العنوان:	Oral phytate supplementation on the progression of mild cognitive impairment, brain iron deposition and diabetic retinopathy in patients with type 2 diabetes: a concept paper for a randomized double blind placebo controlled trial (the PHYND trial)
المؤلفون:	Pujol, Antelm, Sanchis, Pilar, Tamayo, María I., Nicolau, Joana, Grases, Felix, Espino, Ana, Simó-Servat, Olga
المساهمون:	Institut Català de la Salut, Pujol A, Tamayo MI, Nicolau J Vascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain. Sanchis P Vascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain. Laboratory of Renal Lithiasis Research, University of Balearic Islands, Research Institute of Health Science (IUNICS) Health Research Institute of Balearic Islands, (IdISBa), Palma de Mallorca, Spain. Grases F Laboratory of Renal Lithiasis Research, University of Balearic Islands, Research Institute of Health Science (IUNICS) Health Research Institute of Balearic Islands, (IdISBa), Palma de Mallorca, Spain. Espino A Neurology Department, Son Llàtzer University Hospital, Palma de Mallorca, Spain. Simó-Servat O Grup de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus
المصدر:	Scientia
بيانات النشر:	Frontiers Media
سنة النشر:	2024
مصطلحات موضوعية:	Medicació oral, Suplements nutritius, Diabetis no-insulinodependent, Trastorns de la cognició, Retinopatia diabètica, DISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Angiopathies::Diabetic Retinopathy, DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurocognitive Disorders::Cognition Disorders::Cognitive Dysfunction, PHENOMENA AND PROCESSES::Physiological Phenomena::Diet, Food, and Nutrition::Food::Dietary Supplements, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Oral, ENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::angiopatías diabéticas::retinopatía diabética, ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::diabetes mellitus tipo II, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos neurocognitivos::trastornos cognitivos::disfunción cognitiva, FENÓMENOS Y PROCESOS::fenómenos fisiológicos::dieta, alimentación y nutrición::alimentos::suplementos dietéticos, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::vías de administración de medicamentos::administración oral
الوصف:	Mediterranean diet; Cognitive impairment; Phytate ; Dieta mediterrània; Discapacitat cognitiva; Fitat ; Dieta mediterránea; Discapacidad cognitiva; Fitato ; Type 2 diabetes mellitus has a worldwide prevalence of 10.5% in the adult population (20-79 years), and by 2045, the prevalence is expected to keep rising to one in eight adults living with diabetes. Mild cognitive impairment has a global prevalence of 19.7% in adults aged 50 years. Both conditions have shown a concerning increase in prevalence rates over the past 10 years, highlighting a growing public health challenge. Future forecasts indicate that the prevalence of dementia (no estimations done for individuals with mild cognitive impairment) is expected to nearly triple by 2050. Type 2 diabetes mellitus is a risk factor for the development of cognitive impairment, and such impairment increase the likelihood of poor glycemic/metabolic control. High phytate intake has been shown to be a protective factor against the development of cognitive impairment in observational studies. Diary phytate intake might reduce the micro- and macrovascular complications of patients with type 2 diabetes mellitus through different mechanisms. We describe the protocol of the first trial (the PHYND trial) that evaluate the effect of daily phytate supplementation over 56 weeks with a two-arm double-blind placebo-controlled study on the progression of mild cognitive impairment, cerebral iron deposition, and retinal involvement in patients with type 2 diabetes mellitus. Our hypothesis proposes that phytate, by inhibiting advanced glycation end product formation and chelating transition metals, will improve cognitive function and attenuate the progression from Mild Cognitive Impairment to dementia in individuals with type 2 diabetes mellitus and mild cognitive impairment. Additionally, we predict that phytate will reduce iron accumulation in the central nervous system, mitigate neurodegenerative changes in both the central nervous system and retina, and induce alterations in ...
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	application/pdf
اللغة:	English
تدمد:	1664-2392
Relation:	Frontiers in Endocrinology;15; https://doi.org/10.3389/fendo.2024.1332237; Pujol A, Sanchis P, Tamayo MI, Nicolau J, Grases F, Espino A, et al. Oral phytate supplementation on the progression of mild cognitive impairment, brain iron deposition and diabetic retinopathy in patients with type 2 diabetes: a concept paper for a randomized double blind placebo controlled trial (the PHYND trial). Front Endocrinol (Lausanne). 2024 May 30;15:1332237.; https://hdl.handle.net/11351/11603
DOI:	10.3389/fendo.2024.1332237
الاتاحة:	https://hdl.handle.net/11351/11603 https://doi.org/10.3389/fendo.2024.1332237
Rights:	Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess
رقم الانضمام:	edsbas.A8E89D34
قاعدة البيانات:	BASE

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الوصف
تدمد:	16642392
DOI:	10.3389/fendo.2024.1332237