Academic Journal
Ultrasound-Controlled Delivery of Growth Factor-Loaded Cerasomes Combined with Polycaprolactone Scaffolds Seeded with Bone Marrow Mesenchymal Stem Cells for Biomimetic Tendon-to-Bone Interface Engineering.
| العنوان: | Ultrasound-Controlled Delivery of Growth Factor-Loaded Cerasomes Combined with Polycaprolactone Scaffolds Seeded with Bone Marrow Mesenchymal Stem Cells for Biomimetic Tendon-to-Bone Interface Engineering. |
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| المؤلفون: | Du, Cancan, Wu, Ruiqi, Yan, Wenqiang, Fang, Jingchao, Dai, Wenli, Wang, Yiqun, Cheng, Jin, Hu, Xiaoqing, Ao, Yingfang, Liang, Xiaolong, Liu, Zhenlong |
| المصدر: | ACS Appl Mater Interfaces ; ISSN:1944-8252 ; Volume:16 ; Issue:1 |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | cerasome, mesenchymal stem cells, rotator cuff, tendon-to-bone interface, ultrasound-controlled delivery |
| الوصف: | Rotator cuff tear (RCT) is a prevalent shoulder injury that poses challenges for achieving continuous and functional regeneration of the tendon-to-bone interface (TBI). In this study, we controlled the delivery of growth factors (GFs) from liposomal nanohybrid cerasomes by ultrasound and implanted three-dimensional printed polycaprolactone (PCL) scaffolds modified with polydopamine loaded with bone marrow mesenchymal stem cells (BMSCs) to repair tears of the infraspinatus tendon in a lapine model. Direct suturing (control, CTL) was used as a control. The PCL/BMSC/cerasome (PBC) devices are sutured with the enthesis of the infraspinatus tendon. The cerasomes and PCL scaffolds are highly stable with excellent biocompatibility. The roles of GFs BMP2, TGFβ1, and FGF2 in tissue-specific differentiation are validated. Compared with the CTL group, the PBC group had significantly greater proteoglycan deposition (P = 0.0218), collagen volume fraction (P = 0.0078), and proportions of collagen I (P = 0.0085) and collagen III (P = 0.0048). Biotin-labeled in situ hybridization revealed a high rate of survival for transplanted BMSCs. Collagen type co-staining at the TBI is consistent with multiple collagen regeneration. Our studies demonstrate the validity of biomimetic scaffolds of TBI with BMSC-seeded PCL scaffolds and GF-loaded cerasomes to enhance the treatment outcomes for RCTs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.1021/acsami.3c14959; https://pubmed.ncbi.nlm.nih.gov/38133932; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789257/ |
| DOI: | 10.1021/acsami.3c14959 |
| الاتاحة: | https://doi.org/10.1021/acsami.3c14959 https://pubmed.ncbi.nlm.nih.gov/38133932 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789257/ |
| رقم الانضمام: | edsbas.A8CA2B7B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsami.3c14959 |
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