التفاصيل البيبلوغرافية
| العنوان: |
Plasminogen Activator Inhibitor-1 and Vitamin D Association in the Overweight and Obese Pediatric Population |
| المؤلفون: |
Giovina Di Felice, Annamaria D’Alessandro, Anna Pastore, Michela Mariani, Danilo Fintini, Alessia Aureli, Simona Pezzi, Anna Lisa Montemari, Beatrice Barbara Rocco, Andrea Borseti, Andrea Onetti Muda, Melania Manco, Ottavia Porzio |
| المصدر: |
Nutrients; Volume 15; Issue 17; Pages: 3717 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
PAI-1, vitamin D, BMI, children, insulin resistance, HOMA-IR |
| جغرافية الموضوع: |
agris |
| الوصف: |
Background: Childhood overweight and obesity have been described by the World Health Organization as noncommunicable diseases and among the greatest public health threats since they have reached epidemic proportions. A child with obesity risks becoming an adult with obesity and developing metabolic and hemostatic disorders which are the basis for the development of coronary heart diseases. Recently, a number of clinical reports have demonstrated that both an increase in plasminogen activator inhibitor-1 (PAI-1) and a deficiency in 25OH-vitamin D3 (VD) are associated with an increase in thrombotic episodes. Methods: PAI-1 and VD levels were measured in 259 clinically overweight and obese children aged between 2 and 18 years enrolled in the Nutritional Education Program of the Bambino Gesù Children’s Hospital and Research Institute of Rome (Italy) and 80 normal-weight subjects. Results: We observed increased HOMA-IR, PAI-1, and other inflammation indices associated with decreased VD levels when compared to normal-weight children. Conclusions: Our results demonstrated that overweight and obesity are correlated with higher levels of the inflammation index. Moreover, our patients show high PAI-1 and low VD levels, confirming the high thrombotic risk in our pediatric population. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Nutrition and Metabolism; https://dx.doi.org/10.3390/nu15173717 |
| DOI: |
10.3390/nu15173717 |
| الاتاحة: |
https://doi.org/10.3390/nu15173717 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.A890256F |
| قاعدة البيانات: |
BASE |