Academic Journal
Screening utility of a rapid non-invasive dry eye assessment algorithm
| العنوان: | Screening utility of a rapid non-invasive dry eye assessment algorithm |
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| المؤلفون: | Wang, Michael T M, Xue, Ally L, Craig, Jennifer P |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | University of Auckland Research Repository - ResearchSpace |
| مصطلحات موضوعية: | Tears, Humans, Dry Eye Syndromes, Diagnostic Techniques, Ophthalmological, Sensitivity and Specificity, Prospective Studies, Reproducibility of Results, ROC Curve, Osmolar Concentration, Algorithms, Adolescent, Adult, Aged, 80 and over, Middle Aged, Female, Male, Young Adult, Surveys and Questionnaires, Diagnosis, Dry eye, Ocular surface, Screening, TFOS DEWS II, Tear film, 32 Biomedical and Clinical Sciences, 3212 Ophthalmology and Optometry, Women's Health, Clinical Research |
| جغرافية الموضوع: | England |
| الوصف: | Purpose To evaluate the discriminative ability of a rapid non-invasive dry eye assessment algorithm (global evaluation component: SANDE questionnaire, and non-invasive tear film breakup time; subtype classification testing component: tear film lipid layer grade, and tear meniscus height) in detecting dry eye disease, as defined by the TFOS DEWS II diagnostic criteria. Methods Two hundred and thirty-five participants (77 male, 158 female), with a mean ± SD age of 43 ± 17 years, were recruited into a prospective diagnostic accuracy study. OSDI, DEQ-5, and SANDE dry eye symptomology scores; non-invasive tear film breakup time; absolute and inter-ocular differences in tear osmolarity; corneal, conjunctival, and lid margin staining scores; tear film lipid layer, meibum expressibility, meibomian gland orifice plugging, and eyelid margin telangiectasia grades; and tear meniscus height were evaluated in a single clinical session. Results The areas under the ROC curves exceeded 0.80 for all individual components of the rapid non-invasive dry eye assessment algorithm, and the discriminative abilities were significantly greater than chance (all p < 0.001). At the Youden optimal diagnostic thresholds for the global evaluation component of the rapid non-invasive assessment algorithm (SANDE score ≥30, non-invasive tear film break-up time <10 s), the overall sensitivity was 86%, specificity 94%, positive likelihood ratio 15.0, and negative likelihood ratio 0.15. Conclusions The abridged non-invasive dry eye assessment algorithm may be a useful rapid screening instrument for the full TFOS DEWS II diagnostic test battery, of particular benefit in resource or time-constrained settings. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/pdf |
| اللغة: | English |
| تدمد: | 1367-0484 1476-5411 |
| Relation: | Contact lens & anterior eye : the journal of the British Contact Lens Association; (2019). Contact Lens and Anterior Eye, 42(5), 497-501.; https://hdl.handle.net/2292/69486; 30473321 (pubmed); S1367-0484(18)30968-8 |
| DOI: | 10.1016/j.clae.2018.11.009 |
| الاتاحة: | https://hdl.handle.net/2292/69486 https://doi.org/10.1016/j.clae.2018.11.009 |
| Rights: | Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. ; https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm ; Copyright: British Contact Lens Association ; http://purl.org/eprint/accessRights/RetrictedAccess |
| رقم الانضمام: | edsbas.A87359F9 |
| قاعدة البيانات: | BASE |
| تدمد: | 13670484 14765411 |
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| DOI: | 10.1016/j.clae.2018.11.009 |