التفاصيل البيبلوغرافية
| العنوان: |
Investigation of dietary rice bran for protection against Salmonella enterica Typhimurium infection in mice |
| المؤلفون: |
Kumar, Ajay, author, Ryan, Elizabeth P., advisor, Dow, Steven, committee member, Leach, Jan, committee member, Schenkel, Alan, committee member, Weir, Tiffany, committee member |
| بيانات النشر: |
Colorado State University. Libraries |
| سنة النشر: |
2007 |
| المجموعة: |
Digital Collections of Colorado (Colorado State University) |
| مصطلحات موضوعية: |
rice variety, rice bran, fecal shedding, inflammation, Salmonella |
| الوصف: |
2014 Summer. ; Includes bibliographical references. ; Rice bran is a byproduct of rice milling for white rice. Rice bran is a rich source of nutrients such as vitamins, minerals, soluble and insoluble fibers, fatty acids, polyphenols and proteins. Research has shown the beneficial health effects of rice bran in hyperlipidemia, diabetes, immune modulation, allergies and cancer. This dissertation focuses on evaluation of rice bran for protection against Salmonella using a mouse model of oral infection. Salmonella is a food and water borne pathogen that affects a variety of hosts including plants, animals and humans. Salmonella infections are a major public health challenge around the globe. Currently, salmonellosis is treated using high doses of synthetic antimicrobials and the problem of drug resistance has increased. In this scenario, alternative and sustainable interventions are needed to control Salmonella infections. Several dietary agents have been studied for protective effects in Salmonella infection models. We tested the prophylactic effects of dietary rice bran in a Salmonella model of infection using female 129S6/SvEvTac mouse model with infection of Salmonella enterica Typhimurium 14028s strain. Feeding of 10% dietary rice bran for one week prior to infection significantly (p<0.05) reduced fecal excretion of Salmonella in orally infected mice. Salmonella-infected, rice bran fed mice also showed a significant decrease in systemic inflammatory cytokines such as TNF-α, IFN-γ and IL-12 as compared to control diet fed animals. The colonization resistance against enteric pathogens is highly influenced by composition of gut microflora. Supplementation of dietary rice bran increased the number of Lactobacillus spp. in feces of mice as compared to mice that were fed control diet. Research has shown that oral administration of some species of Lactobacillus reduces the colonization of Salmonella. We hypothesized that rice bran components also enhance mucosal protection by preventing Salmonella entry into the ... |
| نوع الوثيقة: |
text |
| وصف الملف: |
born digital; doctoral dissertations; application/pdf |
| اللغة: |
English |
| Relation: |
Kumar_colostate_0053A_12409.pdf; http://hdl.handle.net/10217/83753 |
| الاتاحة: |
http://hdl.handle.net/10217/83753 |
| Rights: |
Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. |
| رقم الانضمام: |
edsbas.A86C19C7 |
| قاعدة البيانات: |
BASE |