Academic Journal
Maintenance of heterogeneity of capillary spacing is essential for adequate oxygenation in the soleus muscle of the growing rat.
| العنوان: | Maintenance of heterogeneity of capillary spacing is essential for adequate oxygenation in the soleus muscle of the growing rat. |
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| المؤلفون: | Degens, H., Deveci, D., Botto-van Bemden, A., Hoofd, L.J.C., Egginton, S. |
| المصدر: | Microcirculation, 13, 6, pp. 467-76 |
| سنة النشر: | 2006 |
| المجموعة: | Radboud University: DSpace |
| مصطلحات موضوعية: | UMCN 2.2: Vascular medicine and diabetes |
| الوصف: | Contains fulltext : 50637.pdf (Publisher’s version ) (Closed access) ; OBJECTIVES: Normal muscle growth is accompanied by capillary proliferation, which usually lags behind the increase in muscle size, causing a decline in mean capillary density (CD). It is not known, however, how the capillary distribution is affected and what impact it has on the oxygenation of the muscle. METHODS: The capillarization of soleus muscles of rats (64-425 g) was determined with the method of capillary domains. As well as quantifying CD, capillary to fiber ratio (C:F), and fiber size, this method provides a measure of the heterogeneity of capillary spacing. Capillary locations were used to mathematically model oxygenation levels within the muscle. RESULTS: The increase in muscle mass was largely attributable to 5-fold increase in fiber size, accompanied by a more than 3-fold rise in C:F. The mismatch between rates of angiogenesis and muscle growth resulted in a decrease in CD. However, the heterogeneity of capillary spacing was unaffected (heterogeneity index logRSD: 0.091 +/- 0.013; mean +/- SD) as was muscle PO2, with modal values between 4 and 60 mmHg (0.5 and 8 kPa). CONCLUSIONS: Angiogenesis during normal muscle growth does not maintain CD, but with similar heterogeneity of capillary spacing it preserves the potential for adequate intramuscular oxygenation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | http://hdl.handle.net/2066/50637 |
| DOI: | 10.1080/10739680600776286 |
| الاتاحة: | http://hdl.handle.net/2066/50637 https://doi.org/10.1080/10739680600776286 |
| رقم الانضمام: | edsbas.A8528179 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/10739680600776286 |
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