Academic Journal
Hippocampal adenosine-to-inosine RNA editing in sepsis: dynamic changes and influencing factors
| العنوان: | Hippocampal adenosine-to-inosine RNA editing in sepsis: dynamic changes and influencing factors |
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| المؤلفون: | Jin, Yun-Yun, Liang, Ya-Ping, Wei, Zhi-Yuan, Sui, Wei-Jia, Chen, Jian-Huan |
| المصدر: | Brain Communications ; ISSN 2632-1297 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2024 |
| الوصف: | Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction secondary to infection. It has been established that factors such as age and sex can significantly contribute to the development of SAE. Our recent study implicated a possible link between adenosine-to-inosine (A-to-I) RNA editing and SAE, yet the dynamics of A-to-I RNA editing during SAE and how it could be influenced by factors such as age, sex, and antidepressants remain uninvestigated. Our current study analyzed and validated transcriptome-wide changes in A-to-I RNA editing in the hippocampus of different septic mouse models. 74 sites in 64 genes showed significant differential RNA editing (DRE) over time in septic mice induced by cecal ligation and perforation (CLP). The DRE might contribute to the RNA expression regulation of the edited genes, with 42.2% differentially expressed. These differentially edited genes, especially those with missense editing, such as glutamate receptor ionotropic kainate 2 (Grik2, p.M620V), filamin A (Flna, p.S2331G), and capicua transcriptional repressor (Cic, p.E2270G), were mainly involved in abnormal social behavior and neurodevelopmental and psychiatric disorders. Significant effects of age and sex were also observed on sepsis-associated RNA editing. Further comparison highlighted 40 common DRE sites that CLP-induced and lipopolysaccharide-induced septic mouse models shared. Interestingly, these findings demonstrate temporal dynamics of A-to-I RNA editing in the mouse hippocampus during sepsis, add to the understanding of age and sex differences in the disease, and underscore the role of the epigenetic process in SAE. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/braincomms/fcae260 |
| DOI: | 10.1093/braincomms/fcae260/58775581/fcae260.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/braincomms/fcae260 https://academic.oup.com/braincomms/advance-article-pdf/doi/10.1093/braincomms/fcae260/58775581/fcae260.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.A846EC47 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/braincomms/fcae260 |
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