Academic Journal
Small node-negative (T1b-cN0) invasive hormone receptor-positive breast cancers: Is there a subpopulation that might have benefit from adjuvant chemotherapy?
| العنوان: | Small node-negative (T1b-cN0) invasive hormone receptor-positive breast cancers: Is there a subpopulation that might have benefit from adjuvant chemotherapy? |
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| المؤلفون: | Park, Yeon Hee, Im, Seock-Ah, Cho, Eun Yoon, Choi, Yoon-La, Lee, Jeong Eon, Nam, Seok Jin, Yang, Jung Hyun, Ahn, Jin Seok, Im, Young-Hyuck |
| المساهمون: | 임석아, Im, Seock-Ah |
| بيانات النشر: | Kluwer Academic Publishers |
| سنة النشر: | 2021 |
| المجموعة: | Seoul National University: S-Space |
| مصطلحات موضوعية: | PATHOLOGICAL COMPLETE RESPONSE, GENE-EXPRESSION PATTERNS, ESTROGEN-RECEPTOR, REPORTING RECOMMENDATIONS, PREOPERATIVE CHEMOTHERAPY, POSTMENOPAUSAL WOMEN, TAMOXIFEN, ANASTROZOLE, SURVIVAL, SUBTYPES, Hormone receptor-positive breast cancer, <, = 1 cm invasive breast cancer, Adjuvant treatment |
| الوصف: | The aims of the study were to identify a subpopulation more likely to be at greater risk of recurrence in small T1b-c node-negative hormone receptor (HR)-positive breast cancer, and which would benefit from adjuvant chemotherapy. Clinico-pathologic characteristics and clinical outcomes of 538 postoperative HR-positive T1b-cN0 breast cancer patients were retrospectively analyzed. High Ki67 index and a young age (< 35 years) were identified as independent risk factors for relapse (p < 0.0001 and 0.015, respectively). A nomogram based on Cox-regression model showed an area under the curve (AUC) of 0.73 in the training set. The validation set showed a good discrimination with an AUC of 0.65. In patients with high nomogram scores (a parts per thousand yen100, n = 24, 4.5%) who had high Ki67 index with more than 75%, or young age (< 35 years) and a Ki67 index > 50%, the relapse-free survival curve of patients who had received anthracycline-containing adjuvant chemotherapy showed a better outcome than those who had not (p = 0.029). Ki67 index and age are valuable surrogate markers to predict recurrence and as indicators of tumors that could benefit from adjuvant chemotherapy in small T1b-c node-negative HR-positive breast cancer. ; N ; 1 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0167-6806 |
| Relation: | Breast Cancer Research and Treatment, Vol.133 No.1, pp.247-255; 123863; https://hdl.handle.net/10371/177184; 000303509200023; 2-s2.0-84860332052 |
| DOI: | 10.1007/s10549-012-1956-1 |
| الاتاحة: | https://hdl.handle.net/10371/177184 https://doi.org/10.1007/s10549-012-1956-1 |
| رقم الانضمام: | edsbas.A808487A |
| قاعدة البيانات: | BASE |
| تدمد: | 01676806 |
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| DOI: | 10.1007/s10549-012-1956-1 |