التفاصيل البيبلوغرافية
| العنوان: |
New Chiral Inhibitors of Induced Platelet Aggregation: the Enantiomeric Specificity of (R)- and (S)-Methyl and Ethyl Esters of 1-{p-[(1-Hydroxycarbonyl)-ethyloxy]-benzyl}-1H-1,2,3-triazole as a Tool for Determining their Biological Target. |
| المؤلفون: |
Biagi G, Catalani R, Gervasi O, Livi O, Scartoni V., GIORGI, IRENE |
| المساهمون: |
Biagi, G, Giorgi, Irene, Catalani, R, Gervasi, O, Livi, O, Scartoni, V. |
| سنة النشر: |
1996 |
| المجموعة: |
ARPI - Archivio della Ricerca dell'Università di Pisa |
| الوصف: |
The synthesis of title enantiomers was accomplished and their biological behaviour as inhibitors of rabbit platelet aggregation process induced by ADP and arachidonic acid was determined. Structure-activity comparison with that of SM-12502 [(2R,5S)-(+)3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride] and Dazoxiben {4-[2-(1H-imidazol-1-yl)-ethoxy]-benzoic acid} allowed us to formulate the possible capability for the synthesized compounds to interact with the biological targets of the model molecules. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/A1996WG66200001; volume:51; firstpage:761; lastpage:766; numberofpages:6; journal:IL FARMACO; http://hdl.handle.net/11568/45415; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0030485477 |
| الاتاحة: |
http://hdl.handle.net/11568/45415 |
| رقم الانضمام: |
edsbas.A7FBF487 |
| قاعدة البيانات: |
BASE |