Dissertation/ Thesis
Avaliação do uso terapêutico de extrato do fungo Trichoderma stromaticum na infecção experimental de camundongos C57BL/6 com Toxoplasma gondii ; Evaluation of the therapeutic use of Trichoderma stromaticum fungus extract in experimental infection of C57BL / 6 mice with Toxoplasma gondii
| العنوان: | Avaliação do uso terapêutico de extrato do fungo Trichoderma stromaticum na infecção experimental de camundongos C57BL/6 com Toxoplasma gondii ; Evaluation of the therapeutic use of Trichoderma stromaticum fungus extract in experimental infection of C57BL / 6 mice with Toxoplasma gondii |
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| المؤلفون: | Sousa, Layane Alencar Costa Nascimento |
| المساهمون: | Silva, Neide Maria da, http://lattes.cnpq.br/4724486896451729 |
| بيانات النشر: | Universidade Federal de Uberlândia Brasil Programa de Pós-graduação em Imunologia e Parasitologia Aplicadas |
| سنة النشر: | 2019 |
| المجموعة: | Universidade Federal de Uberlândia: Repositório Institucional UFU |
| مصطلحات موضوعية: | Toxoplasma gondii, Trichoderma stromaticum, Fase aguda, Intestino delgado, Tratamento da toxoplasmose, Toxoplasmose, Imunologia, Acute phase, Small intestine, Treatment of toxoplasmosis, CNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA::IMUNOLOGIA APLICADA, CNPQ::CIENCIAS BIOLOGICAS::PARASITOLOGIA |
| الوصف: | Trichoderma is well known fungi by inhibit the growth and development of a variety of plant pathogens. The crude ethanolic extract of T. stromaticum (Ext-Ts) are able to decrease the growth of P. falciparum in infected human red blood cells and, increase the survival and prevent neurological signs of P. berghei-ANKA-infected mice. Toxoplasma gondii orally infected C57BL/6 mice develop an inflammatory immune response in the small intestine that depending on the parasite load can lead to death in acute phase or toxoplasmic encephalitis in chronic phase. The most common treatment of toxoplasmosis is based in a combination of sulfadiazine and pyrimethamine, however, numerous collateral side effects have been described. Thus, the aim of this study was to verify the effect of treatment with ExtTs in oral T. gondii-infection of C57BL/6 mice. For this purpose, animals were infected with T. gondii, treated daily with ExtTs, and clinical, biochemical and histological features were monitored. It was observed that the ExtTs-treatment was able to decrease the parasitism and inflammation in the small intestine and liver in acute phase and parasitism in the brain in chronic phase of infection. Additionally, the ExtTs-treatment prevented the increase of lipid fractions systemically which are important for the parasite growth. ; CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ; Tese (Doutorado) ; Trichoderma é um fungo bem conhecido por inibir o crescimento e desenvolvimento de uma variedade de patógenos vegetais. O extrato etanólico bruto de Trichoderma stromaticum (ExtTs) foi capaz de diminuir o crescimento de P. falciparum em hemácias humanas infectadas, aumentar a sobrevivência e prevenir sinais neurológicos em camundongos infectados por P. berghei-ANKA. Camundongos C57BL/6 infectados por via oral com Toxoplasma gondii desenvolvem uma resposta imune inflamatória no intestino delgado que, dependendo da carga parasitária, pode levar à morte na fase aguda ou à encefalite toxoplásmica na fase crônica. O ... |
| نوع الوثيقة: | thesis |
| وصف الملف: | application/pdf |
| اللغة: | Portuguese |
| Relation: | SOUSA, Layane Alencar Costa Nascimento. Avaliação do uso terapêutico de extrato do fungo Trichoderma stromaticum na infecção experimental de camundongos C57BL/6 com Toxoplasma gondii. 2019. 57 f. Tese (Doutorado em Imunologia e Parasitologia Aplicadas) - Universidade Federal de Uberlândia, Uberlândia, 2019. DOI http://doi.org/10.14393/ufu.te.2019.1266.; https://repositorio.ufu.br/handle/123456789/28198; http://doi.org/10.14393/ufu.te.2019.1266 |
| DOI: | 10.14393/ufu.te.2019.1266 |
| الاتاحة: | https://repositorio.ufu.br/handle/123456789/28198 https://doi.org/10.14393/ufu.te.2019.1266 |
| Rights: | Acesso Aberto |
| رقم الانضمام: | edsbas.A7FA8280 |
| قاعدة البيانات: | BASE |
| DOI: | 10.14393/ufu.te.2019.1266 |
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