Academic Journal
Overexpression of Glyoxalase 2 in Human Breast Cancer Cells: Implications for Cell Proliferation and Doxorubicin Resistance
| العنوان: | Overexpression of Glyoxalase 2 in Human Breast Cancer Cells: Implications for Cell Proliferation and Doxorubicin Resistance |
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| المؤلفون: | Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Andrea Frontini, Giulia Casari, Laura Cianfruglia, Giovanna Mobbili, Lidia de Bari, Cinzia Antognelli, Federico V Pallardó, Tatiana Armeni |
| المساهمون: | Romaldi, Brenda, Scirè, Andrea, Minnelli, Cristina, Frontini, Andrea, Casari, Giulia, Cianfruglia, Laura, Mobbili, Giovanna, de Bari, Lidia, Antognelli, Cinzia, V Pallardó, Federico, Armeni, Tatiana |
| سنة النشر: | 2024 |
| المجموعة: | IRIS Università degli Studi di Perugia |
| مصطلحات موضوعية: | S-glutathionylation, breast cancer cell, glyoxalase 2 (Glo2), nucleu, proliferation, redox metabolism |
| الوصف: | Glyoxalase 2 (Glo2) is an enzyme of the glyoxalase system whose pathway parallels glycolysis and which aims to remove methylglyoxal (MGO). This study analyzed the possible additional roles of the Glo2 enzyme in breast cancer (MCF7) and non-cancer (HDF) cell lines, investigating its presence at the nuclear level and its potential involvement in cell proliferation and chemotherapy resistance. The results revealed that Glo2 is overexpressed in cancer cells, and its expression is higher during the proliferative (S and G2/M) phases of the cell cycle. The study also examined a post-translational modification (PTM) in which Glo2 could be involved, with S-glutathionylation revealing that Glo2 enhances this PTM in cancer cells both in the cytoplasm and nucleus. Inhibition of Glo2 by p-NCBG resulted in increased sensitivity to doxorubicin, a common chemotherapeutic agent. This suggests that Glo2 increases cancer cell resistance to chemotherapy, potentially through its role in regulating oxidative stress. These results highlight Glo2 as a potential therapeutic target to improve the efficacy of existing treatments. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39456676; volume:25; issue:20; firstpage:1; lastpage:19; numberofpages:19; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/11391/1586479; https://pubmed.ncbi.nlm.nih.gov/39456676/ |
| DOI: | 10.3390/ijms252010888 |
| الاتاحة: | https://hdl.handle.net/11391/1586479 https://doi.org/10.3390/ijms252010888 https://pubmed.ncbi.nlm.nih.gov/39456676/ https://www.mdpi.com/1422-0067/25/20/10888 |
| رقم الانضمام: | edsbas.A7F84180 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms252010888 |
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