التفاصيل البيبلوغرافية
| العنوان: |
A New Method for the Synthesis of 3-Thiocyanatopyrazolo[1,5-a]pyrimidines |
| المؤلفون: |
Vladimir A. Kokorekin, Sergey V. Neverov, Vera N. Kuzina, Vladimir A. Petrosyan |
| المصدر: |
Molecules; Volume 25; Issue 18; Pages: 4169 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2020 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
thiocyanate group, 5-aminopyrazoles, 1,3-dicarbonyl compounds, pyrazolo[1,5- a ]pyrimidines, anodic C–H thiocyanation, condensation, cyclic voltammetry |
| جغرافية الموضوع: |
agris |
| الوصف: |
In this article, we demonstrate how an original effective “metal-free” and “chromatography-free” route for the synthesis of 3-thiocyanatopyrazolo[1,5-a]pyrimidines has been developed. It is based on electrooxidative (anodic) C–H thiocyanation of 5-aminopyrazoles by thiocyanate ion leading to 4-thiocyanato-5-aminopyrazoles (stage 1, yields up to 87%) following by their chemical condensation with 1,3-dicarbonyl compounds or their derivatives (stage 2, yields up to 96%). This method is equally effective for the synthesis of 3-thiocyanatopyrazolo[1,5-a]pyrimidines, both without substituents and with various donor (acceptor) substituents in the pyrimidine ring. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Organic Chemistry; https://dx.doi.org/10.3390/molecules25184169 |
| DOI: |
10.3390/molecules25184169 |
| الاتاحة: |
https://doi.org/10.3390/molecules25184169 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.A7EC6B01 |
| قاعدة البيانات: |
BASE |