Academic Journal
أعرض في EDS

Individuals With Higher CD4/CD8 Ratio Exhibit Increased Risk of Acute Respiratory Distress Syndrome and In-Hospital Mortality During Acute SARS-CoV-2 Infection

التفاصيل البيبلوغرافية
العنوان: Individuals With Higher CD4/CD8 Ratio Exhibit Increased Risk of Acute Respiratory Distress Syndrome and In-Hospital Mortality During Acute SARS-CoV-2 Infection
المؤلفون: Ana Pascual-Dapena, Juan José Chillaron, Gemma Llauradó, Isabel Arnau-Barres, Juana Flores, Inmaculada Lopez-Montesinos, Luisa Sorlí, Juan Luis Martínez-Pérez, Silvia Gómez-Zorrilla, Juan Du, Natalia García-Giralt, Robert Güerri-Fernández
المصدر: Frontiers in Medicine, Vol 9 (2022)
بيانات النشر: Frontiers Media S.A.
سنة النشر: 2022
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: SARS-CoV-2, prognose, mortality, CD4/CD8 ratio, ARDS, Medicine (General), R5-920
الوصف: BackgroundCD4/CD8 ratio has been used as a quantitative prognostic risk factor in patients with viral infections. This study aims to assess the association between in-hospital mortality and at admission CD4/CD8 ratio among individuals with acute SARS-CoV-2 infection.MethodsThis is a longitudinal cohort study with data of all consecutive patients admitted to the COVID-19 unit at Hospital del Mar, Barcelona, Spain for ≥48 h between March to May 2020. The CD4+ CD8+ T-cell subset differentiation was assessed by flow cytometry at admission as well as a complete blood test. Patients were classified according to CD4/CD8 ratio tertiles. The primary outcome was in-hospital mortality and the secondary outcome was acute respiratory distress (ARDS).ResultsA total of 338 patients were included in the cohort. A high CD4/CD8 ratio (third tertile) was associated with a higher in-hospital mortality [adjusted Cox model hazard ratio (HR) 4.68 (95%CI 1.56–14.04, p = 0.006), reference: second tertile HR 1]. Similarly, a high CD4/CD8 ratio (third tertile) was associated with a higher incidence of ARDS [adjusted logistic regression model OR 1.97 (95%CI 1.11–3.55, p = 0.022) reference: second tertile HR 1]. There was a trend of higher in-hospital mortality and incidence of ARDS in patients within the first tertile of CD4/CD8 ratio compared with the second one, but the difference was not significant. No associations were found with total lymphocyte count or inflammatory parameters, including D-dimer.ConclusionCD4/CD8 ratio is a prognostic factor for the severity of COVID-19, reflecting the negative impact on prognosis of those individuals whose immune response has abnormal CD8+ T-cell expansion during the early response to the infection.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2296-858X
Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.924267/full; https://doaj.org/toc/2296-858X; https://doaj.org/article/1c2e7bea59b24567a512dbd2469476b1
DOI: 10.3389/fmed.2022.924267
الاتاحة: https://doi.org/10.3389/fmed.2022.924267
https://doaj.org/article/1c2e7bea59b24567a512dbd2469476b1
رقم الانضمام: edsbas.A7C97A66
قاعدة البيانات: BASE
ResultId 1
Header edsbas
BASE
edsbas.A7C97A66
938
3
Academic Journal
academicJournal
937.599182128906
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.A7C97A66&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doi.org/10.3389/fmed.2022.924267# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsbas&genre=article&issn=2296858X&ISBN=&volume=&issue=&date=20220101&spage=&pages=&title=Frontiers in Medicine, Vol 9 (2022&atitle=Individuals%20With%20Higher%20CD4%2FCD8%20Ratio%20Exhibit%20Increased%20Risk%20of%20Acute%20Respiratory%20Distress%20Syndrome%20and%20In-Hospital%20Mortality%20During%20Acute%20SARS-CoV-2%20Infection&id=DOI:10.3389/fmed.2022.924267 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Individuals With Higher CD4/CD8 Ratio Exhibit Increased Risk of Acute Respiratory Distress Syndrome and In-Hospital Mortality During Acute SARS-CoV-2 Infection )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Ana+Pascual-Dapena%22">Ana Pascual-Dapena</searchLink><br /><searchLink fieldCode="AR" term="%22Juan+José+Chillaron%22">Juan José Chillaron</searchLink><br /><searchLink fieldCode="AR" term="%22Gemma+Llauradó%22">Gemma Llauradó</searchLink><br /><searchLink fieldCode="AR" term="%22Isabel+Arnau-Barres%22">Isabel Arnau-Barres</searchLink><br /><searchLink fieldCode="AR" term="%22Juana+Flores%22">Juana Flores</searchLink><br /><searchLink fieldCode="AR" term="%22Inmaculada+Lopez-Montesinos%22">Inmaculada Lopez-Montesinos</searchLink><br /><searchLink fieldCode="AR" term="%22Luisa+Sorlí%22">Luisa Sorlí</searchLink><br /><searchLink fieldCode="AR" term="%22Juan+Luis+Martínez-Pérez%22">Juan Luis Martínez-Pérez</searchLink><br /><searchLink fieldCode="AR" term="%22Silvia+Gómez-Zorrilla%22">Silvia Gómez-Zorrilla</searchLink><br /><searchLink fieldCode="AR" term="%22Juan+Du%22">Juan Du</searchLink><br /><searchLink fieldCode="AR" term="%22Natalia+García-Giralt%22">Natalia García-Giralt</searchLink><br /><searchLink fieldCode="AR" term="%22Robert+Güerri-Fernández%22">Robert Güerri-Fernández</searchLink> )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Frontiers in Medicine, Vol 9 (2022) )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Frontiers Media S.A. )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2022 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => Directory of Open Access Journals: DOAJ Articles )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22SARS-CoV-2%22">SARS-CoV-2</searchLink><br /><searchLink fieldCode="DE" term="%22prognose%22">prognose</searchLink><br /><searchLink fieldCode="DE" term="%22mortality%22">mortality</searchLink><br /><searchLink fieldCode="DE" term="%22CD4%2FCD8+ratio%22">CD4/CD8 ratio</searchLink><br /><searchLink fieldCode="DE" term="%22ARDS%22">ARDS</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine+%28General%29%22">Medicine (General)</searchLink><br /><searchLink fieldCode="DE" term="%22R5-920%22">R5-920</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => BackgroundCD4/CD8 ratio has been used as a quantitative prognostic risk factor in patients with viral infections. This study aims to assess the association between in-hospital mortality and at admission CD4/CD8 ratio among individuals with acute SARS-CoV-2 infection.MethodsThis is a longitudinal cohort study with data of all consecutive patients admitted to the COVID-19 unit at Hospital del Mar, Barcelona, Spain for ≥48 h between March to May 2020. The CD4+ CD8+ T-cell subset differentiation was assessed by flow cytometry at admission as well as a complete blood test. Patients were classified according to CD4/CD8 ratio tertiles. The primary outcome was in-hospital mortality and the secondary outcome was acute respiratory distress (ARDS).ResultsA total of 338 patients were included in the cohort. A high CD4/CD8 ratio (third tertile) was associated with a higher in-hospital mortality [adjusted Cox model hazard ratio (HR) 4.68 (95%CI 1.56–14.04, p = 0.006), reference: second tertile HR 1]. Similarly, a high CD4/CD8 ratio (third tertile) was associated with a higher incidence of ARDS [adjusted logistic regression model OR 1.97 (95%CI 1.11–3.55, p = 0.022) reference: second tertile HR 1]. There was a trend of higher in-hospital mortality and incidence of ARDS in patients within the first tertile of CD4/CD8 ratio compared with the second one, but the difference was not significant. No associations were found with total lymphocyte count or inflammatory parameters, including D-dimer.ConclusionCD4/CD8 ratio is a prognostic factor for the severity of COVID-19, reflecting the negative impact on prognosis of those individuals whose immune response has abnormal CD8+ T-cell expansion during the early response to the infection. )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2296-858X )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://www.frontiersin.org/articles/10.3389/fmed.2022.924267/full; https://doaj.org/toc/2296-858X; https://doaj.org/article/1c2e7bea59b24567a512dbd2469476b1 )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.3389/fmed.2022.924267 )
Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://doi.org/10.3389/fmed.2022.924267<br />https://doaj.org/article/1c2e7bea59b24567a512dbd2469476b1 )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.A7C97A66 )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.3389/fmed.2022.924267 ) ) [Languages] => Array ( [0] => Array ( [Text] => English ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => SARS-CoV-2 [Type] => general ) [1] => Array ( [SubjectFull] => prognose [Type] => general ) [2] => Array ( [SubjectFull] => mortality [Type] => general ) [3] => Array ( [SubjectFull] => CD4/CD8 ratio [Type] => general ) [4] => Array ( [SubjectFull] => ARDS [Type] => general ) [5] => Array ( [SubjectFull] => Medicine (General) [Type] => general ) [6] => Array ( [SubjectFull] => R5-920 [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Individuals With Higher CD4/CD8 Ratio Exhibit Increased Risk of Acute Respiratory Distress Syndrome and In-Hospital Mortality During Acute SARS-CoV-2 Infection [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ana Pascual-Dapena ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Juan José Chillaron ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Gemma Llauradó ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Isabel Arnau-Barres ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Juana Flores ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Inmaculada Lopez-Montesinos ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Luisa Sorlí ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Juan Luis Martínez-Pérez ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Silvia Gómez-Zorrilla ) ) ) [9] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Juan Du ) ) ) [10] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Natalia García-Giralt ) ) ) [11] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Robert Güerri-Fernández ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 01 [Type] => published [Y] => 2022 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 2296858X ) [1] => Array ( [Type] => issn-locals [Value] => edsbas ) [2] => Array ( [Type] => issn-locals [Value] => edsbas.oa ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Frontiers in Medicine, Vol 9 (2022 [Type] => main ) ) ) ) ) ) )
IllustrationInfo