Academic Journal
Individuals With Higher CD4/CD8 Ratio Exhibit Increased Risk of Acute Respiratory Distress Syndrome and In-Hospital Mortality During Acute SARS-CoV-2 Infection
| العنوان: | Individuals With Higher CD4/CD8 Ratio Exhibit Increased Risk of Acute Respiratory Distress Syndrome and In-Hospital Mortality During Acute SARS-CoV-2 Infection |
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| المؤلفون: | Ana Pascual-Dapena, Juan José Chillaron, Gemma Llauradó, Isabel Arnau-Barres, Juana Flores, Inmaculada Lopez-Montesinos, Luisa Sorlí, Juan Luis Martínez-Pérez, Silvia Gómez-Zorrilla, Juan Du, Natalia García-Giralt, Robert Güerri-Fernández |
| المصدر: | Frontiers in Medicine, Vol 9 (2022) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | SARS-CoV-2, prognose, mortality, CD4/CD8 ratio, ARDS, Medicine (General), R5-920 |
| الوصف: | BackgroundCD4/CD8 ratio has been used as a quantitative prognostic risk factor in patients with viral infections. This study aims to assess the association between in-hospital mortality and at admission CD4/CD8 ratio among individuals with acute SARS-CoV-2 infection.MethodsThis is a longitudinal cohort study with data of all consecutive patients admitted to the COVID-19 unit at Hospital del Mar, Barcelona, Spain for ≥48 h between March to May 2020. The CD4+ CD8+ T-cell subset differentiation was assessed by flow cytometry at admission as well as a complete blood test. Patients were classified according to CD4/CD8 ratio tertiles. The primary outcome was in-hospital mortality and the secondary outcome was acute respiratory distress (ARDS).ResultsA total of 338 patients were included in the cohort. A high CD4/CD8 ratio (third tertile) was associated with a higher in-hospital mortality [adjusted Cox model hazard ratio (HR) 4.68 (95%CI 1.56–14.04, p = 0.006), reference: second tertile HR 1]. Similarly, a high CD4/CD8 ratio (third tertile) was associated with a higher incidence of ARDS [adjusted logistic regression model OR 1.97 (95%CI 1.11–3.55, p = 0.022) reference: second tertile HR 1]. There was a trend of higher in-hospital mortality and incidence of ARDS in patients within the first tertile of CD4/CD8 ratio compared with the second one, but the difference was not significant. No associations were found with total lymphocyte count or inflammatory parameters, including D-dimer.ConclusionCD4/CD8 ratio is a prognostic factor for the severity of COVID-19, reflecting the negative impact on prognosis of those individuals whose immune response has abnormal CD8+ T-cell expansion during the early response to the infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2296-858X |
| Relation: | https://www.frontiersin.org/articles/10.3389/fmed.2022.924267/full; https://doaj.org/toc/2296-858X; https://doaj.org/article/1c2e7bea59b24567a512dbd2469476b1 |
| DOI: | 10.3389/fmed.2022.924267 |
| الاتاحة: | https://doi.org/10.3389/fmed.2022.924267 https://doaj.org/article/1c2e7bea59b24567a512dbd2469476b1 |
| رقم الانضمام: | edsbas.A7C97A66 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2296858X |
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| DOI: | 10.3389/fmed.2022.924267 |