Academic Journal
Prevention and treatment of bronchopneumonia in mice caused by mouse-adapted variant of avian H5N2 influenza A virus using monoclonal antibody against conserved epitope in the HA stem region.
| العنوان: | Prevention and treatment of bronchopneumonia in mice caused by mouse-adapted variant of avian H5N2 influenza A virus using monoclonal antibody against conserved epitope in the HA stem region. |
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| المؤلفون: | Smirnov, Y.A., Lipatov, A.S., Gitelman, A.K., Claas, E.C.J. (Eric), Osterhaus, A.D.M.E. (Albert) |
| المصدر: | Archives of Virology vol. 145 no. 8, pp. 1733-1741 |
| سنة النشر: | 2000 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | Influenza A Virus, H5N2 Subtype, Animals, Antibodies, Monoclonal/pharmacology/*therapeutic use, Viral/pharmacology/*therapeutic use, Bronchopneumonia/prevention & control/*therapy/virology, Cell Line, Disease Models, Animal, Dose-Response Relationship, Drug, Epitopes/genetics/immunology, Hemagglutinin Glycoproteins, Influenza Virus/genetics/*immunology, Influenza A virus/drug effects/*genetics/immunology, Mice, Molecular Sequence Data, Neutralization Tests, Pneumonia, Viral/prevention & control/*therapy/virology, Sensitivity and Specificity |
| الوصف: | The effects of monoclonal antibody (MAb) C179 recognizing a conformational epitope in the middle of the hemagglutinine (HA) stem region were examined in a mouse model in the experiments of prevention and treatment of lethal bronchopneumonia caused by influenza A virus of H5 subtype. To model the lethal infection, avian nonpathogenic strain A/mallard duck/Pennsylvania/ 10218/84 (H5N2) was adapted to mice. This resulted in highly pathogenic pneumovirulent mouse-adapted (MA) variant, which was characterized. T |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://repub.eur.nl/pub/3728; urn:hdl:1765/3728 |
| DOI: | 10.1007/s007050070088 |
| الاتاحة: | http://repub.eur.nl/pub/3728 https://doi.org/10.1007/s007050070088 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A7BE5763 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s007050070088 |
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